阿托伐他汀对老年大鼠心肌缺血再灌注损伤及多器官功能的保护作用  

Protective effect of atrovastatin against myocardial ischemia-reperfusion injury and on liver and kidney functions in aged rats

作　　者：张今尧[1] 王浩[1] 叶平[1] 

机构地区：[1]解放军总医院南楼心血管内二科,北京100853

出　　处：《南方医科大学学报》2012年第3期322-328,共7页Journal of Southern Medical University

基　　金：国家自然科学基金(30972713)~~

摘　　要：目的观察阿托伐他汀对老年大鼠心肌缺血再灌注过程中心脏的影响,并进一步关注此过程中肝、肾功能的变化。方法10月龄Wistar大鼠饲养至20月龄,阿托伐他汀灌胃至24月龄,分为大剂量他汀组、小剂量他汀组、老年对照组,并设立青年对照组。采用结扎冠状动脉方法建立心肌缺血再灌注模型,纪录缺血再灌注过程中大鼠死亡率、血流动力学变化、心肌梗塞面积变化,及肝肾功能指标。结果与老年对照组相比,青年对照组及大剂量他汀组在缺血再灌注过程中死亡率明显降低(P<0.05)、血流动力学紊乱减少、心梗面积减小(P<0.05);青年对照组及大剂量他汀组在缺血再灌注后,肝肾功能无明显恶化,小剂量他汀组肝脏功能显著恶化(P<0.05),老年对照组肝肾功能均出现显著恶化(P<0.05)。结论阿托伐他汀对老年大鼠心肌缺血再灌注过程中的心、肝、肾多器官产生保护作用。Objuctive To observe the effect of atorvastatin against myocardial ischemia-reperfusion injury and its protective effect on liver and kidney functions. Methods Ten-month-old Wistar rats were fed to the age of 20 months, and atorvastatin statins gavage was administered till 24 months. The rats were divided into high-dose statin group, small-dose statin group, aged control group and young control group. The myocardial ischemia-reperfusion model was established by ligating the coronary artery. The mortality, hemodynamic changes, infarct size and liver and kidney functions of the rats were recorded or measured. Results Compared with the aged control group, the young control group and high-dose statin group showed significantly lower mortality rate, reduced hemodynamic abnormalities, and smaller myocardial infarct size following myocardial ischemia-reperfusion （P〈0.05）. The liver and kidney functions of the young control group and high-dose statin group underwent no significant deterioration after myocardial ischemia and reperfusion, but those in the small-dose statin group and aged control group showed significant deteriorations （P〈0.05）. Conclusion Atorvastatin offers protective effects on the heart, liver, and kidney in the event of myocardial ischemia-reperfusion in aged rats.

关 键 词：老年 阿托伐他汀 缺血再灌注 肝肾功能 

分 类 号：R542.2[医药卫生—心血管疾病]