芫花对豚鼠离体胆囊肌条的作用及其机制初探  

Exploration on the Effect of Genkwa on the Isolated Gallbladder Smooth Muscle of Guinea pig

作　　者：周旭[1] 彭涛[1] 瞿颂义[2] 张英福[2] 丁永辉 卫玉玲 

机构地区：[1]宁夏医学院,银川750004 [2]兰州医学院 [3]甘肃省药检所

出　　处：《山西中医》2000年第1期50-52,共3页Shanxi Journal of Traditional Chinese Medicine

摘　　要：目的:观察不同浓度芫花对胆囊平滑肌运动的影响。方法:用8个灌流肌槽同时记录实验动物胆囊肌条的自发收缩活动。结果:(1)芫花水煎剂可增高离体胆囊肌条的张力,加快收缩频率,减小收缩波平均振幅。(2)酚妥拉明、苯海拉明、消炎痛可部分阻断芫花对胆囊肌条的作用。结论:芫花对豚鼠离体胆囊肌条的作用与肾上腺素α受体、组胺H1受体、前列腺素合成酶有关。Objective:To observe the effect of different concentration of genkwa on gallbladder smooth muscle.Method:Spontaneous contractive activity was observed and recorded with eight tissue chambers.Result:1)The tension of gallbladder muscle,the frequency of tension and the average amplitude highly relied on genkwa dosage.2)Phentolamine,Benzhydramine and indomethactine can patrially block the effect of genkwa.Conclusion:The effect of genkwa on the isolated gallbladder muscle of guinea pig have relation with adrenergic receptor,histamine H 1 receptor and prostaglandin synthelase.

关 键 词：芜花 胆囊平滑肌 阻断剂 实验研究 

分 类 号：R282.710.5[医药卫生—中药学]