氨转运蛋白RhBG在大鼠肾脏集合管的表达  

Expression of ammonia transporter rhbg in renal collecting tubes in rats

作　　者：陈爱英[1] 罗静[2] 

机构地区：[1]太原市第三人民医院检验科,030012 [2]山西医科大学第二医院风湿科

出　　处：《中国药物与临床》2012年第3期297-299,共3页Chinese Remedies & Clinics

基　　金：山西省国际科技合作项目(2011081071);山西省留学人员科研资助项目(200810102)

摘　　要：目的观察氨转运蛋白Rhbg在低蛋白饮食大鼠肾脏集合管的表达。方法利用定量免疫组织化学法分别检测低蛋白饮食组和正常对照组氨转运蛋白Rhbg在大鼠肾脏皮质、内髓、外髓集合管的表达。结果低蛋白饮食可以明显增加Rhbg在大鼠肾脏皮质部集合管的表达(P<0.05),但不改变Rhbg在大鼠肾脏内髓和外髓集合管的表达。结论饮食中蛋白的限制可能会增加Rhbg在大鼠肾脏皮质部集合管的表达。Objective To determine the renal expression of ammonia transporters Rhbg in rats fed with lowprotein diet. Methods For low-protein diet group and normal control group, the expression of Rhbg in renal cortex, inner medulla and outer medulla in rats was detected via quantitative immunohistoehemistry assay. Results Rats fed with low-protein diets were shown to have considerably higher Rhbg expression in renal cortex （P〈0.05）, but not in inner or outer medulla. Conclusion Restriction of dietary protein may result in elevated Rhbg expression in renal cortex.

关 键 词：肾小管 集合 载体蛋白质类 大鼠 

分 类 号：R692[医药卫生—泌尿科学]