榼藤子生品和炮制品总皂苷体内抗肿瘤作用  

Experimental Study on Anti-tumor Effect of the Total Saponins from the Crude and Processed Products of Entada phaseoloides

作　　者：邓悟红 肖二[2] 熊慧[2] 莫莎莎[2] 梅之南[2] 

机构地区：[1]武汉市黄陂区中医医院,武汉430300 [2]中南民族大学药学院,武汉430074

出　　处：《中国实验方剂学杂志》2012年第6期148-150,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81073150);国家科技支撑计划项目(2007BAI48B08)

摘　　要：目的:考察榼藤子生品和炮制品总皂苷体内抗肿瘤作用。方法:荷瘤小鼠随机分为8组,接种后第2天给药,连续10 d,模型对照组ig以等量生理盐水,阳性对照组腹腔注射顺铂3 mg.kg-1,低、中、高剂量榼藤子生品、炮制品总皂苷组分别ig 0.25,0.5,1 g.kg-1剂量。观察榼藤子总皂苷的肿瘤抑制作用;计算抑瘤率、胸腺指数、脾指数、肝脏指数;测定血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:榼藤子生品高、中、低剂量组的抑瘤率分别为58.86%,49.52%,43.45%,榼藤子炮制品高、中、低剂量组的抑瘤率分别为59.41%,48.81%,44.59%,榼藤子生品及炮制品总皂苷还能提升荷瘤小鼠血清SOD的活力,降低MDA水平。结论:榼藤子生品和炮制品总皂苷具有抗小鼠肿瘤作用,并可增强抗氧化能力。Objective： To study the anti-tumor action of total saponins from the crude and processed products of Entada phaseoloides in vivo. Method： Mice bearing transplanted tumor S180 were used to observe the effects of total saponins from E. phaseoloides; then inhibition ratio, thymus index, spleen index and liver index were calculated. The level of superoxide dismutase （SOD） and malondialdehyde （MDA） was detected. Result： The crude and processed products E. phaseoloides saponins showed a significant anti-cancer activity on S180 implanted in mice, increased the level of SOD and reduced the content of MDA in blood serum in tumor-bearing mice. Conclution： The crude and processed products E. phaseoloides saponins have anti-tumor effects andanti oxidative capacity.

关 键 词：榼藤子 总皂苷 抗肿瘤 炮制 

分 类 号：R285.5[医药卫生—中药学]