养心康片对慢性心功能不全模型兔心功能,TNF-α,IL-6的影响  

Effects of Yangxinkang Tablet on Cardiac Function,TNF-α and IL-6 in Rabbit with Chronic Heart Failure

作　　者：任培华[1] 冼绍祥[2] 杨忠奇[2] 陈洁[2] 

机构地区：[1]广州医学院第一附属医院,广州510120 [2]广州中医药大学第一附属医院,广州510405

出　　处：《中国实验方剂学杂志》2012年第6期237-240,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广州市科技局项目(2008A1-E4101)

摘　　要：目的:观察养心康片对慢性心功能不全模型兔心功能、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)的影响。方法:应用结扎兔冠状动脉的方法建立兔慢性心力衰竭动物模型,随机分为模型组、卡托普利组、养心康片低、中、高剂量组,并设立空白对照组,每组5只。造模后第5天开始给药。卡托普利组给予卡托普利1.2 mg.kg-1;养心康片低、中、高剂量组分别给予养心康片(0.17,0.51,1.53 g.kg-1),ig每天1次。空白对照组和模型组给予等体积的蒸馏水,共4周。观察养心康片对心衰模型兔心功能,TNF-α,IL-6的影响。结果:空白对照组的左室舒张末容积(LVEDV)最低(2.20±1.14)mL,与模型组比较,其间差别有统计学意义(P<0.01)。模型组的LVEDV最高(4.12±1.19)mL,与卡托普利组、养心康片中、高剂量组比较,其间差别有统计学意义(P<0.05)。空白对照组LVEF值最高(83.60±2.79)%,与模型组比较,其差别有统计学意义(P<0.01)。模型组的左室射血分数(LVEF)值最低(64.80±12.07)%,与养心康中、高剂量组比较,其间的差别有统计学意义(P<0.01)。空白对照组的TNF-α,IL-6的水平最低,与模型组比较差别有统计学意义(P<0.01)。模型组的TNF-α,IL-6的水平最高,与养心康片各剂量组比较其差别有统计学意义(P<0.05)。结论:养心康片可以改善心衰模型兔心功能,降低心衰模型兔血清的TNF-α,IL-6水平。Objective： To observe the effects of Yangxinkang tablet on cardiac function, tumor necrosis factor-α （TNF-α） and interleunin-6 （IL-6） in rabbit with chronic heart failure. Method： The rabbit heart failure animal model was established by blocking left anterior descending coronary artery. The rabbits were randomly divided into model group, captopril group, low dose group, middle dose group and high dose group of Yangxinkang tablet, the normal control group was set, with 5 rabbits in each group. After 5days of modelling, captoprilat dose of 1.2 mg. kg-1 and Yangxinkang tablet at dosage of 0. 17, 0.51, 1.53 g . kg-lwere orally administrated once a day for 4 weeks. The effects of Yangxinkang tablet on cardiac function, TNF-α and IL-6 were investgated. Result： The left ventricular end diastolic volum （LVEDV） in control group was lowest （2.20 ± 1. lg） mL, compared with model group （4.12 -1.19） mL, the difference was statistically significant （P 〈 0.01）, and compared with model group, middle dose group, high dose group and captopril group showed satistically significant （P 〈 0.05）.

关 键 词：养心康片 慢性心功能不全 心功能 肿瘤坏死因子-Α 白介素-6 

分 类 号：R285.5[医药卫生—中药学]