慢性阻塞性肺病动物模型在药理研究中的应用  

Animal Models of Chronic Obstructive Pulmonary Disease in Pharmacological Research

作　　者：于绍帅[1,2] 陈明苍[1] 季宇彬[2] 谭英姿[3] 俞仲毅[4] 张炜[3] 

机构地区：[1]中国科学院上海药物研究所,上海201203 [2]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [3]上海中医药大学附属曙光医院,上海201203 [4]上海中医药大学,上海201203

出　　处：《中国实验方剂学杂志》2012年第6期275-278,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项“重大新药创制”课题(2009ZX09301-001)

摘　　要：对慢性阻塞性肺病(COPD)动物模型研究的国内外报道进行文献整理,对COPD模型的建立以及COPD治疗药物开发提供新的思路。通过中科院上海药物研究所图书数据库平台查阅近几年国内外有关慢性阻塞性肺病和动物模型为关键字的研究报道30余篇,进行分析综合。总结了几种动物作为COPD动物模型的优势和缺陷,并归纳建立COPD模型的相关方法和评价造模成功的判断相关指标,为COPD模型的建立提供参考。COPD疾病的发病过程复杂至今没能有国际统一的标准建模方法,报道多是几种方法联合进行造模;希望能为COPD的研究者选择模型提供一点参考,为新的治疗COPD的药物的开发铺路,期望在不远的将来能够建立标准化统一的COPD治疗与研究方法。The animal models of chronic obstructive pulmonary disease were reviewed and analyzed. It is hoped to provide a new train of chronic obstructive pulmonary disease （COPD） therapeutic drug development. Data on COPD and animal models in recent years were searched by the CAS Shanghai institute of materia database platform. The advantages and disadvantages of several animals as a COPD animal model were summarized, and the methods for COPD model and the relevant indicators to judge the successfulness of COPD model were established. Because of the complex pathogenesis of the COPD, it was failed to approach a unified COPD modeling standard. The article reported that several method unions are mostly used. This review hopes to provide some reference for the new treatments for COPD drug development. We expect to establish a standardized model of COPD for the disease treatment and research in the future

关 键 词：慢性阻塞性肺疾病 动物模型 药理 

分 类 号：R285.5[医药卫生—中药学]