中国沿海常见棘毒鱼类的毒性研究——日本鬼鱼由背鳍棘中Ⅰ型毒腺细胞形成的研究  

Toxicity research of spine poisoning fish Freguently found in China coastal waters——Regeneration of type Ⅰ cells in venom gland of Synanceja Inimicus japonicus

作　　者：刘晓萍[1] 张克凌[2] 于业军[3] 孙衍增[2] 王海青[4] 方丽华[1] 秦士德[3] 

机构地区：[1]青岛大学医学院组织胚胎学教研室 [2]青岛大学医学院化学教研室 [3]青岛大学医学院附属医院皮肤科 [4]青岛大学科研处,山东青岛266021

出　　处：《海洋环境科学》2000年第1期20-23,共4页Marine Environmental Science

基　　金：国家自然科学基金!资助项目 ( 392 70 64 5 ) ;山东省教委资助!项目 (J91K0 1 )

摘　　要：用光、电镜方法研究了日本鬼鱼由背鳍棘中Ⅰ型毒腺细胞的形成过程。结果表明 :位于背鳍棘两侧纵沟内的毒腺组织周围有较致密的结缔组织的鞘膜包绕 ,该鞘膜钝性剥离后可见内面光滑 ,有Ⅰ型和Ⅱ型毒腺细胞的痕迹。而毒腺组织内下侧与毒棘的骨组织相连处结缔组织疏松 ,有许多小的梭形细胞 ;在梭形细胞之间及周围有新形成的幼稚腺细胞 ,其组织结构类似Ⅰ型毒腺细胞。透射电镜下可见该区域的结缔组织中除结缔组织的细胞及纤维成分以外 ,有许多大小不同的细胞 ,细胞单核 ,胞质内各种细胞器(粗面内质网、高尔基复合体、线粒体等 )发达。在不同的细胞内有形态和数量不同的类似溶酶体样物质 ,其内涵物类似Ⅰ型毒腺细胞胞质结构。推测毒腺组织内的毒腺细胞的发生与腺体下内侧的结缔组织内的梭形细胞有关 ,Ⅰ型细胞由幼稚细胞发育而来。The development of type Ⅰ cells in venom gland of Synanceja Inimicus japonicus was studied using a light microscopy, transmission and scanning electromicroscopy. At adjacent portion between the bone tissue of spine and connective tissue around the venom gland, there were many small spindle cells. Among these spindle cells some round or polygonal cells were found, which cytoplasm was similar to type Ⅰ cells, but weak basophilic and the size was smaller than type Ⅰ cells. Transmission electromicroscopy showed these smaller cells contained rough endoplasmic reticulum, Golgi complex, lysosome like material and other organelle. The number of lysosome like material in the different cells were varying. The structure of lysosome like material was similar to the cytoplasm of type Ⅰ cells. The fusion of those lysosome like material could be observed. The results suggested that spindle cells could be undifferentiated cells which could give rise to the basophilic immature cells, then the immature cells developed into type Ⅰ cells.

关 键 词：日本鬼You Ⅰ型 毒腺细胞 鳍棘 棘毒鱼 毒性 

分 类 号：R996.3[医药卫生—毒理学] R595.8[医药卫生—药学]