2型糖尿病患者晨尿微量白蛋白／肌酐与24h尿微量白蛋白相关性分析  

Correlation Analysis of Morning Microalbuminuria/Urine Creatinine and 24-h Microalbuminuria in Patients with Type 2 Diabetes Mellitus

作　　者：仇海燕[1] 谢云[1] 李露荃[2] 韩丽萍[1] 冯克娜[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病神经内科,卫生部及天津市激素与发育重点实验室,300070 [2]北京理工大学国际经济与贸易学院

出　　处：《天津医药》2012年第3期209-211,共3页Tianjin Medical Journal

摘　　要：目的：研究2型糖尿病（T2DM）患者晨尿微量白蛋白（MALB）/肌酐（Cr）影响因素及用晨尿MALB/Cr评估尿蛋白排泄的可行性。方法：收集179例T2DM患者晨尿和24h尿,测定晨尿MALB、Cr、24h尿MALB及其他各项生化指标,并按肌酐清除率（Ccr）分为25.66-49mL/min、50-79mL/min、≥80mL/min3组,进行各项生化指标与晨尿MALB/Cr的相关性分析。结果：晨尿MALB/Cr与年龄、体质指数（BMI）、DM病程、24h尿MALB、24h尿蛋白（24h尿TP）、收缩压（SBP）、舒张压（DBP）、糖尿病视网膜病变（DR）呈正相关。DM病程、SBP、DR是T2DM患者晨尿MALB/Cr的影响因素。Ccr≥25.66mL/min时,各组晨尿MALB/Cr与24h尿MALB呈正相关。结论：晨尿MALB/Cr可代替24h尿MALB,用于观察尿蛋白排泄情况并对2型糖尿病肾病进行检测和评估,此测定适用于尿量Ccr≥25.66mL/min的不同Ccr的T2DM患者。Objective： To investigate the influential factors of the first morning microalbuminuria （MALB） / urine creatinine （Cr）, and explore the feasibility of replacing 24 h MALB monitoring by measuring morning MALB/ Cr in patients with type 2 diabetes mellitus （T2DM）. Methods： Samples of morning urine and 24 h urine were obtained from 179 patients with T2DM. The levels of morning urine MALB, Cr, 24-h MALB and other biochemical indicators were measured. Patients were divided into three groups according to the Cr clearance rate （Ccr） of 25.66-49 mL/min,50-79 mL/min and ≥80 mL/min. The correlation between biochemical indicators and MALB/Cr in morning urine was analyzed. Results： The value of MALB/Cr was positively correlated with age, body mass index（BMI）, 24-h MALB, 24-h urine protein, systolic blood pressure （SBP）, diastolic blood pressure （DBP） and diabetic retinopathy （DR）. The duration of diabetes, SBP and DR were the independent risk factors of MALB/Cr in morning urine of T2DM patients. There was a positive correlation between morning MALB/Cr and 24-h MALB, when Ccr≥25.66 mL/min. Conclusion： Detection of MALB/Cr in morning urine can replace 24-h MALB to evaluate diabetic nephropathy in T2DM patients, which can be applied in T2DM patients with Ccr≥25.66 mL/min.

关 键 词：糖尿病 2型糖尿病肾病白蛋白类肌酸酐糖尿病视网膜病变白蛋白尿 

分 类 号：R259.872[医药卫生—中西医结合]