纵向应力作用下的血管重建  

Vascular remodeling under axial tension

作　　者：韩海潮[1,2,3] 姜宗来[2] 

机构地区：[1]美国德克萨斯大学圣安东尼奥分校机械工程系 [2]上海交通大学生命科学技术学院,力学生物学与医学工程研究所,上海200240 [3]西安交通大学航空航天学院,西安710049

出　　处：《医用生物力学》2012年第1期7-12,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金资助项目(10928206);美国国家科学基金会(CAREER0644646);NIH(HL095852,HHSN 268201000036C UTH-SCSA Cardiovascular Proteomics Center)部分资助

摘　　要：在体血管除了受到血压和剪切血流外,还受到显著的纵向张力作用。纵向张力影响血管的生理功能及其对血压和血流的响应。虽然对血压和血流改变时的血管重建已有了很多了解,但对血管纵向应变及其相应的血管组织重建却了解甚少。本文总结了血管纵向张力和应变的在体观测结果,以及血管对纵向应力改变的细胞和组织层次的响应与适应性重建。增加纵向张力导致组织重建,过度减少纵向张力会导致血管发生屈曲。纵向张力作用下血管组织重建的研究将增强对血管正常生理功能和病理变化的认识。Arteries in vivo are subjected to lumen pressure,shear flow and axial tension due to surrounding tissue tethering.The axial stress affects arterial function including its response to pressure and flow.While the effects of blood pressure and shear flow are well documented,the effects of axial tension on vascular remodeling have just gradually gained attention recently.This review summarizes the results on the observation of the axial tension in arteries and responses of arteries to elevation and reduction of the axial stress.It is concluded that the axial tension in arteries plays an important role in regulating normal arterial function and tissue remodeling and adaptation and disease development.Research on vascular remodeling under axial tension shall strengthen the understanding of normal physiological functions and pathological changes of the arteries.

关 键 词：血管重建 纵向张力 机械应力 血管 血压 生物力学 

分 类 号：R318.01[医药卫生—生物医学工程]