短期应用左卡尼汀在卵细胞胞质内单精子注射治疗少弱精子症中的作用  

Short-term medication of L-carnitine before intracytoplasmic sperm injection for infertile men with oligoasthenozoospermia

作　　者：吴正沐[1] 陆湘[1] 王永卫[1] 孙健[1] 陶皆唯[1] 尹峰华[1] 程怀瑾[1] 

机构地区：[1]上海交通大学附属国际和平妇幼保健院生殖中心,上海200030

出　　处：《中华男科学杂志》2012年第3期253-256,共4页National Journal of Andrology

摘　　要：目的:观察左卡尼汀短期治疗男性少弱精子症后精液质量的变化及行卵细胞胞质内单精子注射(intracytoplasmic sperm injection,ICSI)助孕治疗后的临床结果。方法:研究对象为根据WHO标准检测精液分析结果为少弱精子症者129例,治疗组42例服用左卡尼汀2周后应用ICSI,对照组87例单纯应用ICSI助孕技术。对比治疗组患者用药前后精液精子浓度、活动率、(a+b)级精子百分率、畸形率指标,治疗组与对照组对比ICSI后受精率、卵裂率、有效胚胎率、临床妊娠率。结果:治疗组患者治疗后(a+b)级精子百分率(13.5±10.7)%,较治疗前(9.6±7.2)%提高(P<0.05),治疗组ICSI操作后有效胚胎率77.50%,明显高于对照组69.04%(P<0.05)。结论:左卡尼汀短期治疗能够改善精子质量,并有助于少弱精子症患者提高ICSI治疗的成功率。Objective： To observe the pregnancy promoting effect of L-carnitine combined with intracytoplasmic sperm injection （ICSI） in treating male infertility with oligoasthenozoospermia. Methods： We assigned 129 patients with oligoasthenozoospermia to receive 2 weeks of oral L-carnitine followed by ICSI （ medication group, n = 42） and ICSI alone （ control group, n = 87）. We compared the sperm concentration and motility, the percentage of grade a ＋ b sperm, and sperm deformity before and after L-carnitine medication, as well as the rates of fertilization, cleavage, available embryo and clinical pregnancy between the two groups. Results ： The percentage of grade a ＋ b sperm was significantly increased after L-carnitine medication as compared with the baseline （ [ 13.5 ± 10.7]% vs [ 9.6 ± 7.2 ] %, P 〈 0. 05）, and so was the rate of available embryo in the medication group after ICSI in comparison with that of the control group （77.50% vs 69.04%, P 〈 0. 05 ）. Conclusion ： Short-term medication of L-carnitine can improve sperm quality and raise the success rate of ICSI. Natl J Androl, 2012, 18 （3） ： 253 -256

关 键 词：左卡尼汀 少弱精子症 不育 卵细胞胞质内单精子注射 

分 类 号：R698.2[医药卫生—泌尿科学]