植物性雌激素对子宫内膜及异位子宫内膜的影响  

Influence of Phytoestrogen on Endometrium and Ectopic Endometrial Focus

作　　者：吉梅[1] 陈超[2] 林流芳[1] 刘玉环[1] 蔡在龙[2] 俞超芹[3] 

机构地区：[1]第二军医大学上海长海医院妇产科,上海200433 [2]第二军医大学上海长海医院中心实验室,上海200433 [3]第二军医大学上海长海医院中医妇科,上海200433

出　　处：《生殖与避孕》2012年第3期185-189,共5页Reproduction and Contraception

基　　金：国家自然基金重点资助项目;项目编号:30930113;2010.01~2013.12

摘　　要：植物性雌激素(phytoestrogens,PEs)是一类结构及生物学活性类似于雌激素的天然非甾体类化合物,可与雌激素受体结合,对内源性雌激素起双向调节作用。研究表明,植物雌激素可以缓解妇女围绝经期相关症状,且不会引起子宫内膜的复杂型增生及癌变;植物雌激素还能降低子宫内膜癌的发病风险,具有一定抗癌作用;此外,植物雌激素通过其弱的雌激素活性,既能抑制体内异位病灶的生长又能避免发生骨质疏松等副作用,将会给子宫内膜异位症(EMs)患者带来福音。Phytoestrogens（PEs） is a group of natural non-steroid compound which displays estrogen-like activity because of their structural similarity to endogenous estrogens and exhibits high affinity binding to estrogen receptor（ER）,which have two-way adjustment to endogenous estrogens.Researches have implied that phytoestrogens exert benificial roles in relief of perimenopausal syndrome,meanwhile,they will not cause complicated hyperplasy and canceration of endometrial.Phytoestrogens can also depress the onset risk of endometrial cancer.They exert antitumous effect at some extent.In addition,phytoestrogens can inhibit growth of ectopic focus without side effects such as osteoporosis in endometriosis through its weak estrogenic activity,which will be a gospel to the patients who are suffering endometriosis.

关 键 词：植物性雌激素(PEs) 子宫内膜增生 子宫内膜癌 子宫内膜异位症(EMs) 

分 类 号：R711[医药卫生—妇产科学]