砷中毒对大鼠骨密度影响的实验研究  

Experimental study of the effect of arsenic poisoning on bone mineral density in rats

作　　者：杨海霞[1] 刘佰林[1] 栾立[1] 孙梅[1] 张鹏[2] 李白艳[2] 

机构地区：[1]新疆医科大学附属自治区中医医院影像中心新疆医科大学附属自治区中医医院影像中心,乌鲁木齐830000 [2]新疆医科大学第一附属医院影像中心

出　　处：《中国骨质疏松杂志》2012年第2期146-148,共3页Chinese Journal of Osteoporosis

摘　　要：目的在慢性砷中毒实验中研究不同浓度砷对大鼠骨密度的影响。方法 Wistar大鼠40只,雌雄各半,随机分为4组,其中3组高、中、低砷染毒组分别饮用砷(As3-)浓度为34、8.5、2.125mg/L的含砷水,对照组饮用蒸馏水。饲养2、4和6个月时使用双能X线骨密度仪测量大鼠双侧股骨骨密度(BMD)。结果各染砷组组间比较:染毒2、4、6个月时骨密度比较均为高氟组≈中氟组≈低氟组≈对照组(P>0.05);各实验组组内骨密度比较:高砷组、中砷组、低砷组及对照组均为2月≈4月≈6月(P>0.05)。结论不论染砷时间长短或浓度大小砷都不会显著影响大鼠的骨密度。Objective To explore the effect of arsenic with different concentration on the bone mineral density（BMD） through the chronic arsenic poisoning experiment in rats.Methods Forty Wistar rats,20 males and 20 females,were randomly classified into 4 groups.The rats in the high dose,middle dose,and low dose group were administered with the arsenic concentrations of 34,8.5,and 2.125 mg/L,respectively.The rats in the control group were fed with water.The bilateral femoral BMD of rats was measured with dual-energy X-ray densitometry at the 2 months,4 months,and 6 months after administration.Results The comparison of BMD among rats in the 4 different groups at the 2 months,4 months,and 6 months after administration showed that BMD was nearly similar and there was no significant difference（P0.05）.The comparison of BMD among different measuring time of rats in the 4 different groups showed that the BMD measured at 2 months was nearly similar to BMD measured at 4 months and 6 months in every group（P0.05）.Conclusion No matter the time length or arsenic concentration,arsenic cannot significantly affect the BMD of rats.

关 键 词：大鼠 砷中毒 骨密度 骨质疏松 骨质硬化 

分 类 号：R965[医药卫生—药理学]