硝唑尼特的合成与表征  

Synthesis and Characterization of Nitazoxanide

作　　者：徐庐峰 冯晓亮 吴微 许丹萍 

机构地区：[1]衢州学院化学与材料工程学院,浙江省衢州市324000

出　　处：《光谱实验室》2012年第2期843-846,共4页Chinese Journal of Spectroscopy Laboratory

基　　金：浙江省科技厅公益性项目(No.2011C31036);浙江省大学生科技创新项目(No.2010R427011);浙江省衢州市科技局项目(No.20101055)

摘　　要：邻乙酰水杨酸经氯化亚砜酰氯化制得邻乙酰水杨酰氯,以N,N′-二乙基甲酰胺为溶剂,吡啶为缚酸剂,与2-氨基-5-硝基噻唑缩合反应制得硝唑尼特,收率为78.9%(以2-氨基-5-硝基噻唑计),含量为98.8%(HPLC)。化合物结构经1H NMR、IR确证。o-Acetylsalicylryl chloride was synthesized by acetylsalicylic acid and sulfurous oxychloride.Nitazoxanide was synthesized by 2-amino-5-nitro-thiazole and o-acetylsalicylryl chloride,with N,N′-diethylformamide as solvent and pyridine as tied acid agents,The yield was 78.9% with 2-amino-5-nitro-thiazole as calculation,and the purity of nitazoxanide was 98.8% by HPLC.The structure of the product was identified by IR and 1H NMR.

关 键 词：邻乙酰水杨酸 硝唑尼特 2-氨基-5-硝基噻唑 

分 类 号：TQ463[化学工程—制药化工] O657.33[理学—分析化学]