慢性稳定性心绞痛合并糖尿病患者循环microRNA-92a表达研究  

Circulatory level of microRNA 92a in patients of stable angina pectoris with diabetes mellitus

作　　者：王虹[1] 林英忠[1] 周莹[2] 陆红梅[1] 陆山河[1] 罗程[1] 赵林[2] 

机构地区：[1]广西壮族自治区人民医院心内科,广西南宁530021 [2]广西壮族自治区人民医院中心实验室,广西南宁530021

出　　处：《中国现代医学杂志》2012年第6期26-29,共4页China Journal of Modern Medicine

基　　金：广西省医药卫生重点科研课题(No:2010026)

摘　　要：目的了解循环miR-92a在慢性稳定性心绞痛(SAP)合并2型糖尿病患者中的表达,探讨循环miR-92a在冠心病临床应用的可能性。方法分析比较慢性稳定性心绞痛合并2型糖尿病患者、SAP无糖尿病合并症患者循环miR-92a表达。结果方差成份分析,糖尿病对SAP循环miR-92a表达的贡献(偏差平方和16.676)是年龄对SAP循环miR-92a表达贡献(偏差平方和2.474)的6倍多。以年龄为协变量,协方差分析SAP合并糖尿病病例入院次日循环miR-92a表达水平显著高于SAP无糖尿病合并症病例(F=21.86,P=0.001)。SAP合并糖尿病病例多支血管病变发生率73.3%(22/30)显著高于SAP无糖尿病合并症病例多支血管病变发生率51.2%(44/86)(χ2=4.458,P=0.035)。结论 SAP合并糖尿病病例循环miR-92a表达增高。SAP合并糖尿病病例较无糖尿病病例冠脉病变严重。提示针对循环miR-92a表达增高的合并糖尿病的SAP进行干预治疗的临床实际应用价值值得进一步深入研究。[ Objective ] To investigate circulatory level of microRNA 92a （miR-92a） in patients with stable angi- na pectoris （SAP） complicated with type 2 diabetes mellitus （T2DM）. [Methods] To determine the regulation of miR-92a, we detected it in peripheral blood mononuclear cells of patients of SAP with or without T2DM. Based on the circulating miR-92a .in patients with SAP, the influence factors were explored with variance component model. [Results] Contribution of T2DM was six times higher than age in miR-92a expression according to variance com- ponent model （sum of squared deviations were 16.676 vs 2.474）. MiR-92a expression was higher in patients with T2DM than those without T2DM （F =21.86, P =0.001）. The rate of multivessel coronary artery lesions was higher in patients of SAP with T2DM than those without T2DM （73.3% vs 51.2%, P =0.035）. [Conclusion] MiR-92a is up- regulation in patients with SAP complicated with T2DM. The rate of multivessel coronary artery lesions is higher in patients with T2DM than those without T2DM. It implies miR-92a could be used as blood biomarker to prevent SAP complicated T2DM development.

关 键 词：心绞痛 糖尿病 MICRORNA 表达 

分 类 号：R541[医药卫生—心血管疾病] R587[医药卫生—内科学]