非布司他降解产物的LC-MS研究  

Study on Degradation Products of Febuxostat by LC-MS

作　　者：冷柏榕[1,2] 严相平[1] 王康蕊[1] 王德才[2] 

机构地区：[1]南京工业大学江苏省药物研究所,南京210009 [2]南京工业大学药学院,南京211816

出　　处：《中国现代应用药学》2012年第3期226-229,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究非布司他的降解产物。方法强制降解后以LC-MS测定,根据质谱测定结果结合结构及反应机制推测降解产物结构。结果推测降解产物为2-[3-氰基-4-(2-异丁氧基)苯基]-4-甲基噻唑-5-羧酸甲酯、2-[3-氨基甲酰基-4(2-异丁氧基-)苯基]-4-甲基噻唑-5-羧酸、2-[3-氰基-4-(2-异丁氧基)苯基]-4-甲基-1-氧化噻唑-5-羧酸甲酯以及非布司他的二聚体。结论该法为研究非布司他的稳定性及其可能的降解途径提供了参考。OBJECTIVE To investigate the degradation products of febuxostat. METHODS After forced degradation, products were determined by LC-MS. The structures of degradation products were elucidated by the results of mass spectrometry combined with the structure and the reaction mechanism. RESULTS It was speculated that the degradation products were 2-（3-cyano-4-isobutoxy-phenyl）-4-methyl-thiazole-5-carboxylic acid methyl ester, 2-（3-carbamoyl-4-isobutoxyphenyl）-4- methylthiazole-5-carboxylic acid, 2-（3-cyano-4-isobutoxy-phenyl）-4-methyl-1-oxidation thiazole -5-carboxylic acid methyl ester, a dimmer of febuxostat. CONCLUSION The method provides a reference of studying the stability of febuxostat and possible degradation pathway.

关 键 词：非布司他 液相色谱-质谱 有关物质 降解产物 

分 类 号：R917.101[医药卫生—药物分析学]