头孢噻利与甲硝唑注射液的配伍稳定性考察  

Compatible Stability of Cefoselis Sulsate with Metronidazole Injection

作　　者：雷虹[1] 华俊彦[1] 田伟强[1] 张丽芬[1] 

机构地区：[1]丽水市中心医院药剂科,浙江丽水323000

出　　处：《中国现代应用药学》2012年第3期274-276,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省医学会基金项目(2007ZYC57)

摘　　要：目的考察头孢噻利与甲硝唑氯化钠注射液的配伍稳定性。方法采用高效液相色谱法(HPLC)测定头孢噻利与甲硝唑氯化钠注射液配伍8 h内的含量变化,并考察其外观、pH值变化。结果头孢噻利与甲硝唑氯化钠注射液配伍后,8 h内二者含量变化不大,溶液澄清,pH值基本稳定。结论头孢噻利与甲硝唑氯化钠注射液可配伍使用。OBJECTIVE To study the compatible stability of cefoselis Sulsate with metronidazole injection. METHODS The content of the mixture of cefoselis sulsate and metronidazole within 8 h were determined by HPLC, meanwhile the changes in appearances and the pH values were observed. RESULTS The content ofcefoselis sulsate and metronidazole injection was stable within 8 h. The mixture was clear, pH value was also stable. CONCLUSION Cefoselis sulsate can be mixed with metronidazole injection for clinical use.

关 键 词：头孢噻利 甲硝唑注射液 配伍稳定性 

分 类 号：R969.2[医药卫生—药理学]