扁平苔藓中Ki-67和VEGF的表达  

Expressions of Ki-67 and vascular endothelial growth factor in lichen planus

作　　者：王娟[1] 白莉[2] 鲍海平[1] 郑爱义[1] 武晓华[1] 赵一锦[1] 邓起[1] 米希婷[1] 

机构地区：[1]山西大同大学医学院,037009 [2]山西医科大学第一医院皮肤科,太原市030001

出　　处：《实用医学杂志》2012年第6期916-918,共3页The Journal of Practical Medicine

摘　　要：目的:研究扁平苔藓皮损中Ki-67和血管内皮生长因子(VEGF)的表达情况,探讨它们在扁平苔藓发病中的作用。方法:采用免疫组化法检测20例扁平苔藓皮损中Ki-67和VEGF的表达情况,20例正常皮肤作为对照。结果:扁平苔藓组中Ki-67和VEGF的表达水平明显高于对照组,差别具有统计学意义(P<0.01);扁平苔藓皮损中Ki-67和VEGF的表达呈正相关(r=0.74,P<0.01)。结论:Ki-67、VEGF的异常高表达可能参与了扁平苔藓的发病。Objective To investigate the expressions of Ki-67 and vascular endothelial growth factor （VEGF） in lichen planus and explore their effects on the pathogenesis of lichen planus. Methods The expressions of Ki-67 and VEGF in 20 lichen planus and 20 normal skin specimens were detected by immunohistochemical method. Results The expressions Ki-67 and VEGF were significantly higher in lichen planus than those in normal skins （P 〈 0.01 ）. There was a positive correlation between the expression of Ki-67 and VEGF in lichen planus （r = 0.74, P 〈 0.01）. Conclusions The up-regulated expressions of Ki-67 and VEGF may play an important role in the develonment of lichen nlanus.

关 键 词：真菌病 扁平苔藓 KI-67 血管内皮生长因子 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]