2008-2010年ICU铜绿假单胞菌耐药性分析  

Drug resistance of Pseudomonas aeruginosain intensive care unit from 2008 to 2010

作　　者：林德[1] 毛剑锋[1] 陈丽芬[1] 

机构地区：[1]丽水市人民医院检验科,浙江丽水323000

出　　处：《中华医院感染学杂志》2012年第5期1035-1036,共2页Chinese Journal of Nosocomiology

摘　　要：目的了解ICU铜绿假单胞菌(PAE)的耐药性,为指导临床用药及控制感染提供依据。方法回顾性调查2008年1月-2010年12月ICU PAE感染的临床情况,对571株PAE的药敏试验结果进行统计分析。结果 3年分离的571株PAE主要来自呼吸道标本,占75.7%;测定的多数抗菌药物耐药率呈逐年上升趋势,2010年有9种抗菌药物的耐药率>40.0%,2010年亚胺培南和美罗培南的耐药率分别较2009年降低8.0%和1.2%。结论PAE的耐药性已十分严重,应定期监测ICU PAE耐药情况,为临床合理用药提供参考,同时加强对抗菌药物合理使用的管理。OBJECTIVE To analyze the drug resistance of Pseudemonas aeruginosa（PAE） from ICU,so as to provide evidence for clinical application of antibiotics and control of infections.METHODS The resistance status of 571 strains of PAE isolated from ICU specimens were analyzed by retrospective study method from Jan.2008 to Dec.2010.RESULTS Totally 571 strains of PAE were mainly from respiratory tract specimens,accounting for 75.7%.The resistance rates to most of the tested antibiotics increased year by year.The resistance rates to 9 antimicrobial agents were over 40.0% in 2010.The resistance rates to imipenem and meropenem in 2010 decreased by 8.0% and 12%,respectively,as compared with those in 2009.CONCLUSION The resistance of P.aeruginosa has been very serious.Regular surveillance for the drug resistance of PAE should be carried out in ICU to provide reference for clinical rational use of antibiotics.Meanwhile,we should strengthen the management of reasonable use of antibiotics.

关 键 词：铜绿假单胞菌 抗菌药物 药物敏感试验 耐药性 

分 类 号：R378.991[医药卫生—病原生物学]