前列清颗粒对大鼠慢性非细菌性前列腺炎的作用  

Effects of Qianlieqing Granule on Chronic Abacterial Prostatitis in Rats

作　　者：陈志强[1] 何羿婷[2] 陈更新[2] 徐琳本[3] 桂泽红[1] 董倩倩[3] 张琼[1] 

机构地区：[1]广东省中医院泌尿外科,广州510120 [2]广东省中医院新药开发中心,广州510120 [3]湖南省中医药研究院中药研究所,长沙410013

出　　处：《中药新药与临床药理》2012年第2期128-131,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家中医药管理局新药开发专项课题(D2X034B);广东省科技计划项目(2005B33001012);广州市科技攻关计划引导项目(2005Z3-E5021)

摘　　要：目的评价前列清颗粒对慢性非细菌性前列腺炎模型大鼠的治疗作用。方法采用消痔灵致慢性非细菌性前列腺炎大鼠模型,设前列清颗粒高、中、低剂量组以及前列泰胶囊对照组、模型组和空白对照组,灌胃给药,共45 d。给药后检测全血和前列腺液中白细胞数、前列腺液中卵磷脂小体密度,并对前列腺组织进行病理学观察。结果与模型组比较,前列清三个剂量组前列腺液中白细胞数及前列腺指数均明显降低(P<0.05,P<0.01);前列清中、高剂量组全血中白细胞数明显降低,大鼠卵磷脂小体密度明显升高,前列腺的病理改变明显减轻(P<0.05,P<0.01)。结论前列清颗粒对模型大鼠慢性非细菌性前列腺炎有明显治疗作用。Objective To evaluate the therapeutic effects of Qianlieqing Granule（QG） on rat models of chronic abac terial prostatitis（CAP）. Methods The rat models of CAP were established by injection of Xiaozhiling. The rats weredivided into six groups： model group, blank control group, etai Capsule（QC） group. The rats were given gastric gavage high, moderate and lowdosage QG groups and Qianli of corresponding drugs for 45 days according to the exper imental design. After treatment, white blood cell（WBC） count in whole blood and prostatic fluid, and lecithin cor puscle density in prostatic fluid were examined. Moreover, the pathological changes of prostate tissues were observed. Results The number of WBC in prostatic fluid and prostatic index of QG groups were significantly lower than those in the model group（P 〈 0.05 or P 〈 0.01 ）. Moderate- and high-dosage QG significantly lowered the number of WBC in whole blood, increased the density of lecithin corpuscle, and relieved the pathological changes of rat prostatic tissues （P 〈 0.05 or P 〈 0.01 ）. Conclusion QG has significant therapeutic effects on CAP in rat models.

关 键 词：前列清颗粒 慢性非细菌性前列腺炎 白细胞数 卵磷脂小体密度 

分 类 号：R285.5[医药卫生—中药学]