盐酸氨溴索治疗慢性阻塞性肺疾病急性发作期80例临床观察  

Clinic observation on the ambroxol in treatment of 80 cases with acute exacerbation of chronic obstructive pulmonary disease

作　　者：常琦[1] 

机构地区：[1]贵州省毕节地区医院,贵州毕节551700

出　　处：《现代预防医学》2012年第6期1591-1593,共3页Modern Preventive Medicine

摘　　要：目的观察盐酸氨溴索治疗慢性阻塞性肺疾病急性发期的临床疗效。方法将符合病例入选标准的160例慢性阻塞性肺疾病急性发作期患者随机分为观察组、对照组,每组80例。2组患者均给予解痉平喘、抗感染、纠正水电解质失衡和营养支持等常规治疗,同时吸入信必可都保,每次1格,每日2次。观察组同时给予盐酸氨溴索注射液静脉滴注,每次30mg,每日2次。2组均以治疗1周为1个疗程,治疗2个疗程后观察疗效。结果显效率观察组为75.00%,对照组为53.75%,2组相比差异有统计学意义(P﹤0.05);总有效率观察组为94.56%,对照组为74.75%,2组相比差异有统计学意义(P﹤0.05)。PaO2、PaCO2、SaO2、PEF等指标2组治疗前后组内相比较差异有统计学意义(P﹤0.05);治疗后2组组间比较差异有统计学意义(P﹤0.05)。治疗后2组Cdyn、MVV、FEV0.3、Fres、Zrs、R5-R20等指标相比差异均有统计学意义(P﹤0.05);FVC、2组FVC、R5%、R20%、X5、Rc、Rp等指标相比差异无统计学意义(P﹤0.05)。结论采用盐酸氨溴索治疗慢性阻塞性肺疾病急性发期患者具有良好的临床疗效,可显著改善患者肺功能各项指标。OBJECTIVE To observe on the clinic efficacy of ambroxol in treatment of acute exacerbation of chronic obstructive pulmonary. METHODS 160 patients with acute exacerbation of chronic obstructive pulmonary disease were selected and randomly divided into two groups according to the inclusion criteria, including 80 cases in each group. The two groups were given spasm and asthma, antibiotics, correct water and electrolyte imbalance and nutritional support and other conventional treatment, while inhaling symbicort turbuhaler, each time a cell, 2 times a day. Observation group were given ambroxo] intravenous injection, each 30rag, 2 times a day. Two groups were treated for 1 week for a course of treatment, and the effects were observed after 2 courses, RESULTS The efficiency of the observation group was 75.00%, and was 53.75% for the control group, there was significant difference in the 2 groups （P 〈 0.05） ; The total effective of the observation group was 94.56%, and was 74.75% for the control group, there was significant difference in the 2 groups （P〈 0.05）. The Pa02, PaC02, Sa02 and PEF and other indicators of the two groups before and after treatment were significantly difference （P 〈 0.05） ; There was significant difference in the two groups after treatment （P〈 0.05）. After treatment, the Cdyn, MVV, FEV0.3, Fres, Zrs, R5- R20 and other indicators of the 2 groups were significant difference （P 〈 0.05）; The FVC, R5%, R20%, X5, Re, Rp and other indicators of the two groups did not show significant difference （ P 〉 0.05）. CONCLUSION The effect of ambroxol in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease is good, which can significantly improve lung function in patients with various indicators.

关 键 词：慢性阻塞性肺疾病:急性发作 盐酸氨溴索 肺功能 

分 类 号：R563[医药卫生—呼吸系统]