细辛脑注射剂致不良反应122例文献分析  

Literature Analysis of 122 Adverse Drug Reactions Induced by Asarone Injection

作　　者：杨怀勇[1] 邓永平[2] 

机构地区：[1]云南省肿瘤医院药剂科,云南昆明650000 [2]四川省平昌县人民医院药剂科,四川平昌636400

出　　处：《中国民族民间医药》2012年第6期36-37,39,共3页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:探讨细辛脑注射剂致不良反应的规律和特点,指导临床合理用药。方法:检索1994～2011年国内公开发行的医药期刊,对细辛脑注射剂致不良反应病例进行分析。结果:共检索到细辛脑注射剂致不良反应病例122例,男性72例,女性50例;本组病例中共101例年龄在10岁以下,占全部病例的82.79%;不良反应多发生在给药30min以内;不良反应以一般过敏性反应、过敏性休克、消化系统类反应及心血管系统等反应为主。结论:细辛脑注射剂的使用导致的不良反应的在儿童中更易发生,其表现有速发型和多系统损害的特点,应引起临床高度重视。Objectiae： To discuss the general characteristics of the ADRs induced by asarone injection, and provide guideline for rational drug use in clinic. Methods： The ADR cases induced by asarone injection reported in domestic medical journals from 1994 to 2011 were collected and statistically analyzed. Results： Among the 122 ADR cases, the proportions of the male and female patients were 59. 02% （72/122） and 40. 98% （50/122）, and the proportions of ADR that happened to children （≤10years） was82. 79% （101/122）. Most of the ADR induced by asarone injection occurred within 30 minutes after medication. The allergic reaction, allergic shock, digestive system reaction and cardiovascular system reaction were occupied mostly in ADR cases. Conclusion： The ADRs induced by asarone injection happened to children more easy and had characteristics of immediately and multisystem damage, doctors should use the asarone injection strictly, and pay more attention to the ADRs.

关 键 词：细辛脑注射剂 不良反应 文献分析 

分 类 号：R961.1[医药卫生—药理学]