男性性功能低下的发病机制及治疗靶点  

Possible Mechanisms and Therapeutic Targets of Male Hypogonadism

作　　者：刘桂来[1] 于锋[1] 戴德哉[1] 戴茵[1] 

机构地区：[1]中国药科大学药理研究室,江苏南京210009

出　　处：《药学进展》2012年第3期104-109,共6页Progress in Pharmaceutical Sciences

基　　金：国家"重大新药创制"科技重大专项(No.2009ZXJ09004-070);国家自然科学基金(No.81070145)

摘　　要：男性性功能低下严重影响患者生活质量,近年来其发生率有增长之势,已成为当今医药研究的热门课题。综述男性性功能低下的发病机制及治疗靶点,简介相关药物研发现状。Male hypogonadism, of which the incidence has shown an upward trend in recent years, affects the patients＇ life quality seriously and has been the focus of medical research nowadays. The possible mechanisms and therapeutic targets of male hypogonadism were reviewed. The development status of the related drugs was introduced briefly.

关 键 词：男性性功能低下 睾丸病变 内皮素 氧化应激 内质网应激 炎症细胞因子 

分 类 号：R698[医药卫生—泌尿科学] R965.1[医药卫生—外科学]