胰岛素对骨骼肌微血管的调节作用  

Effects of insulin on microvascular recruitment of skeletal muscle

作　　者：胡晓琳[1] 娄宁[1] 董振华[1] 许大帅[1] 胡苏[1] 王文汇[1] 

机构地区：[1]山东大学附属济南市中心医院内分泌科,250013

出　　处：《国际内分泌代谢杂志》2012年第2期107-110,共4页International Journal of Endocrinology and Metabolism

基　　金：基金项目：国家自然科学基金资助项目（81070632）

摘　　要：骨骼肌血管系统有丰富的分支网状结构，近年来人们多采用测定1-甲基黄嘌呤（1-MX）的代谢情况、对比增强超声成像（CEU）、激光多普勒超声仪（LDF）和实时对比超声等方法检测骨骼肌微血管的灌注情况。研究发现，胰岛素在未改变骨骼肌大动脉血流量的情况下，就可以引起骨骼肌微循环灌注的增加，而且这一作用具有剂量依赖性；而存在胰岛素抵抗时，胰岛素对阻力动脉的调节作用受损。胰岛素对血管的调节作用与其介导的一氧化氮和内皮素-1的表达密切相关，胰岛素抵抗时二者的表达失衡。Skeletal muscle is rich in microvascular system. Recent years,many techniques have been used to measure microvaseular recruitment in skeletal muscle, such as the measurement of metabolism of 1-methylxanthine （ 1-MX）, contrast-enhanced ultrasound （ CEU ）, laser Doppler flowmetry （ LDF ）, real-time contrast imaging and so on. Studies showed that insulin increases skeletal muscle microvascular perfusion in a dose-dependent manner without influencing blood flow. However, this effect was impaired by insulin resistance. The regulation effects of insulin were in close relationship with the expression of nitric oxide and endo- thelin-1. Insulin resistance will lead to the unbalanced expression of them.

关 键 词：骨骼肌 胰岛素 微血管灌注 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]