视黄醇结合蛋白4与糖尿病血管并发症  

Relationship between retinol binding protein 4 and diabetic vascular complications

作　　者：张志莹[1] 李强[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌科 激素与内分泌疾病重点实验室,150081

出　　处：《国际内分泌代谢杂志》2012年第2期114-116,共3页International Journal of Endocrinology and Metabolism

基　　金：基金项目：教育部高等学校博士学科点专项科研基金资助项目（200802260007）

摘　　要：糖尿病血管并发症的发生机制复杂，与高血糖及胰岛素抵抗、炎性反应、氧化应激密切相关。视黄醇结合蛋白4（RBP4）作为一种脂肪细胞因子，可通过胰岛素抵抗、脂代谢紊乱、氧化应激、炎性反应导致动脉粥样硬化的发生及血管扩张，参与糖尿病大血管病变的发生。RBP4也与糖尿病微血管并发症的发生相关，但其具体机制有待进一步研究。运动、减重手术、贝特类调脂药、格列酮类的干预可降低RBP4水平，有望成为治疗糖尿病血管病变的新策略。The pathogenesis of diabetic vascular disease is complex. It is closely related with high blood glucose, insulin resistance, inflammation, oxidative stress. As an adipocytokine, retinol binding protein 4 （RBP4） participates in atherosclerosis and vascular expansion through insulin resistance, lipid metabolism disorders, oxidative stress and inflammatory reaction, finally leads to diabetic vascular disease. RBP4 is also associated with the pathogenesis of microvascular complications, however, the specific mechanism needs further study. Exercise, lose weight surgery, cholesterol lowering agents--fibrates and the glitazones can reduce RBP4 level, which indicates RBP4 is a new strategy for the treatment of diabetic vascular disease.

关 键 词：视黄醇结合蛋白4 糖尿病血管病变 动脉粥样硬化 氧化应激 炎症 

分 类 号：R587.2[医药卫生—内分泌]