糖尿病心肌病发病机制的研究进展  

Pathogenesis of diabetic cardiomyopathy

作　　者：谭学莹[1] 赵林双[1] 

机构地区：[1]广州军区武汉总医院内分泌科,武汉430070

出　　处：《国际内分泌代谢杂志》2012年第2期127-130,共4页International Journal of Endocrinology and Metabolism

基　　金：基金项目：湖北省重点攻关课题（2006AA301B61-2）

摘　　要：糖尿病心肌病是糖尿病最严重的并发症之一，是一类独立的特异性心肌病。临床主要表现为心室舒张功能受损和心功能不全。其发病机制复杂，目前认为能量代谢紊乱、细胞凋亡、氧化应激、心肌间质纤维化、微血管病变、心脏自主神经病变等多个方面导致其发生、发展。临床中部分糖尿病患者在严格控制血糖后仍可并发糖尿病心肌病。因此，进一步探究糖尿病心肌病发病机制，可望为糖尿病心肌病的防治提供新思路。Diabetic cardiomyopathy, one of the most serious complications of diabetes mellitus, is an independent specific cardiomyopathy. The damage of ventrieular diastolic function and cardiac insufficiency are the most common symptoms. The complexity of pathogenesis comprise energy metabolic disorder, apoptosis, oxidative stress, the cardiac interstitial fibrosis, microvascular lesion and cardiac autonomic neuropathy. Clinically, some diabetic patients under the strict control of blood glucose still developed diabetic cardiomyopathy. Therefore, further to explore the pathogenesis of diabetic cardiomyopathy may help to provide a new approach for the prevention and treatment of diabetic cardiomyopathy.

关 键 词：糖尿病 心肌病 发病机制 

分 类 号：R587.2[医药卫生—内分泌]