α-环糊精修饰型香豆素的设计合成  

Design and Synthesis of α-Cyclodextrin Modified Coumarin

作　　者：江金强 陈欣 殷明 王周平[2] 刘晓亚 陈明清 

机构地区：[1]江南大学化学与材料工程学院,无锡214122 [2]江南大学食品学院,无锡214122

出　　处：《化学学报》2012年第5期525-529,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.20704017;50973044);江苏省高校"青蓝工程"资助项目;中央高校基本科研业务费专项资金(No.JUSRP31003)资助项目~~

摘　　要：以环氧氯丙烷为桥接,利用水溶性α-环糊精(α-CD)进行7-羟基-4-甲基香豆素的功能化修饰,得到新型α-环糊精修饰型香豆素衍生物(α-CD-C).用傅里叶变换红外(FT-IR)光谱、氢核磁共振(1H NMR)、液质联用(LC-MS)等对该香豆素衍生物进行了结构表征.紫外光二聚实验表明,该α-环糊精修饰型香豆素可在365 nm光照下进行光二聚反应,且可在随后的254 nm光照下进行解二聚反应;同时通过比较该交替光照下的光二聚反应程度,可知该光二聚反应仅是部分可逆的.A Using epichlorohydrin as the bridged unit, the water-soluble a-cyclodextrin （a-CD） was intro- duced to modify 7-hydroxy-4-methylcoumarin and prepare the novelα-cyclodextrin modified coumarin （a-CD-C）, which was characterized by FTIR, 1H NMR and LCMS. The photo-dimerization experiment showed that a-CD-C could photo-dimerize upon 365 nm irradiation, and then photo-de-crosslink upon the subsequent 254 nm irradiation. And by comparing the photo-dimerization degree upon 365 nm and 254 nm irradiation, it was concluded that the photo-dimerization reaction is only partially reversible.

关 键 词：香豆素 环糊精 合成 紫外光 二聚 

分 类 号：O621.3[理学—有机化学]