成都地区中老年人血尿酸水平与高血压关系的研究  

Association between serum uric acid and hypertension among the community-dwelling residents in Chengdu

作　　者：靳红[1] 王宾友[1] 刘雅[1] 何萍[2] 黄晓波[1] 欧阳凌云[1] 

机构地区：[1]成都市第二人民医院,四川成都610017 [2]成都市第三人民医院,四川成都610031

出　　处：《西部医学》2012年第3期470-473,共4页Medical Journal of West China

基　　金：成都市"十一五"科技规划重大专项(编号:07YTYB959SF-020)

摘　　要：目的探讨成都地区中老年人血尿酸(Serum uric acid,SUA)水平与高血压的关系。方法利用成都地区慢性病防治项目的现况调查资料,分析年龄40岁及40岁以上中老年人群的资料,比较不同年龄、性别中的SUA水平及高尿酸血症(HUA)患病率,并进一步分析不同SUA水平对血压水平和高血压患病率的影响。结果该人群SUA平均水平为(295.85±83.10)μmol/L,其中男性为(344.25±83.81)μmol/L,女性为(265.93±67.01)μmol/L;HUA总体患病率为11.36%,其中男性为15.94%,女性为8.97%,男性明显高于女性(P<0.01)。男性SUA水平和HUA患病率在50岁以后逐渐升高,女性SUA水平和HUA患病率随年龄逐渐升高。随SUA水平的增高,收缩压水平、舒张压水平及高血压患病率呈明显的升高趋势。相关分析显示,SUA水平与血压呈正相关。Logistic回归分析显示,以SUA四分位最低层为对照,在第二、三、四分位层时患高血压症的OR值分别为1.27、1.60和2.21,差异均有统计学意义(P<0.01)。结论成都地区社区中老年人群HUA的患病率较高,尤其是男性人群患病率明显高于女性。SUA水平与血压密切相关,SUA水平升高是高血压的危险因素。尿酸干预对降低社区人群高血压的发生发展可能有重要意义。Objective To estimate the serum uric acid（SUA） levels and the prevalence of hyperuricemia（HUA） among the community-dwelling residents in Chengdu area,and investigate the association between SUA and blood pressure in this population.Methods A cross-sectional population-based survey for chronic diseases in Chengdu was performed in 2008.By analyzing the data of population aged 40 years and over,we compared the SUA levels and the prevalence of HUA in different ages and genders,and further analyzed the associations between different levels of SUA with blood pressure and prevalence of hypertension.Results The average SUA level was 295.85±83.10umol/L in this population,344.25±83.81umol/L in male and 265.93±67.01umol/L in female.The total prevalence of HUA was 11.36%,15.94% in male and 8.97% in female.Both SUA level and prevalence of HUA were significantly higher in men than women（P0.01）.SUA levels and prevalence of HUA were increasing gradually after age 50 in men,but they were increasing gradually with age in women.Systolic blood pressure,diastolic blood pressure levels and prevalence of hypertension were significantly increased with the elevated levels of SUA.Correlation analysis showed SUA level was positively correlated with blood pressure.Logistic regression analysis showed that compared with the lowest quartile,the odds ratio of the prevalence of hypertension were 1.27,1.60 and 2.21 respectively.The differences were statistically significant（P0.01）.Conclusion The HUA is highly prevalent among the community middle-aged and elderly in Chengdu area,especially in the male population.SUA is closely correlated with blood pressure.Elevated level of SUA is a risk factor to hypertension.There may be a potential significance to reducing the incidence and the development of hypertension by intervening SUA in the community-dwelling people.

关 键 词：血尿酸 高尿酸血症 血压 高血压 

分 类 号：R589[医药卫生—内分泌]