儿宝颗粒对小儿厌食症动物模型下丘脑CCK-8和β-EP的调节作用  

EFFECTS OF ERBAO GRANULES ON CCK 8 AND β EP IN HYPOTHALAMUS OF JUVENILE ANIMAL MODEL WITH ANOREXIA

作　　者：杜永平[1] 张月萍[1] 汪受传 隆红艳 史健[1] 吴少华[1] 

机构地区：[1]中国人民解放军第四军医大学西京医院,西安710032 [2]南京中医药大学第一临床医学院

出　　处：《安徽中医学院学报》2000年第1期39-41,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：国家自然科学基金!资助课题 (NO .3 9670 896)

摘　　要：目的:研究运脾复方儿宝颗粒对小儿厌食症动物模型下丘脑CCK8和βEP的调节作用。方法:模拟小儿厌食症的主要病因制作幼龄大鼠厌食模型,用儿宝颗粒治疗,用放射免疫检测技术测定实验动物下丘脑CCK8和βEP的含量。结果:模型动物下丘脑CCK8浓度显著增高(P<0.05),βEP浓度无明显变化(P>0.05);儿宝颗粒治疗组CCK8含量恢复正常,βEP含量显著增高(P<0.01)。结论:儿宝颗粒能明显抑制该模型下丘脑CCK8分泌,同时促进下丘脑βEP分泌。Objective:To study the effects of Erbao Granules on CCK 8 AND β EP in hypothalamus of juvenile animal model with anorexia.Method:The model was established by imitating the major cause of children anorexia,and then was treated with Erbao Granules.The CCK 8 and β EP concentration in hypothalamus of animals were examined by radioimmunoassay.Resust:There was an obvious increase of CCK 8 concentration in the model(P<0.05) which can be cured by Erbao Granulas.And no change in β EP of model,but it increased significantly in large dose group(P<0.01).Conclusion:Erbao Granules was effective on decreasing CCK 8 and increasing β EP concentration in hypothalamus of the animal model.

关 键 词：厌食 CCK-8 Β-EP 儿宝颗粒 中医药疗法 儿童 

分 类 号：R272.605[医药卫生—中医儿科学] R285.5[医药卫生—中医学]