冠状动脉钙化与冠心病危险因素的相关性  

Relationship between coronary artery calcification and risk factors of coronary heart disease

作　　者：王冬梅[1] 贾国良[2] 韩雅玲[1] 佟铭[1] 李菲[1] 荆全民[1] 苗志林[1] 王祖禄[1] 刘振春[1] 关长群[1] 

机构地区：[1]沈阳军区总医院心内科,辽宁沈阳110015 [2]第四军医大学西京医院心血管内科,陕西西安710033

出　　处：《第四军医大学学报》2000年第1期61-63,共3页Journal of the Fourth Military Medical University

摘　　要：目的　探讨冠状动脉钙化 (CAC)与 CHD危险因素之间的关系 ,以增加 CT诊断 CHD的敏感性和可靠性 .方法　 1 88例住院患者均行冠脉造影及冠脉 CT检查 ,并详细记录病史及冠心病的危险因素 .结果　年龄 <45岁者 CAC对CHD诊断的特异性较高 ,冠脉狭窄≥ 75 %组 CAC诊断 CHD的阳性预告值明显高于狭窄 <75 %组 (P<0 .0 5 ) .在 45～ 5 9岁年龄组中 ,CAC诊断 CHD的敏感性和特异性均较高 .高血压及高脂血症患者 ,CAC阳性率增加 (P<0 .0 5 ) ,且冠状动脉钙化者所伴的危险因素明显高于无冠脉钙化者 (P<0 .0 5 ) .结论　年龄 <6 0岁时 CAC预测 CHD的可能性强 ,随着年龄的增加 ,CAC诊断 CHD的特异性下降 . CAC与 CHD的危险因素同时存在 ,提示 CHD的危险因素有促进亚临床AIM The relation between coronary artery calcification (CAC) and risk factors of coronary heart disease (CHD) was studied in order to improve the sensitivity and reliability of CHD diagnosed by computerized tomography (CT). METHODS 188 in patients were examined by coronary angrography (CAG) and CT and the case history and risk factors of CHD were recorded. RESULTS Among the patients younger than 45 years, the specifity of CAC diagnosis to CHD was much higher. The predictive value of CHD by CAC was obviously higher in ≥75% artery narrowing group than in <75% group ( P <0.05). Both sensitivity and specifity of CHD by CAC were high in the group with the age 45 to 59 years. Among the patients with hypertension and hlyperchole sterolemia, the CAC positive rate increased ( P <0.05). The risk factors of patients with CAC were higher than those without CAC ( P <0.05). CONCLUSION Under the age of 60 years, the specifity of CHD diagnosis by CAC is good but it decreases with the increase of age. Both CAC and risk factors of CHD exist, indicating that the risk factors of CHD can stimulate clinical CHD development.

关 键 词：冠状血管造影术 冠心病 危险因素 CT 

分 类 号：R541.4[医药卫生—心血管疾病]