结核分枝杆菌Ag85A DNA疫苗抗结核作用的研究  

Immunotherapeutic effect of Ag85A DNA vaccine on tuberculosis

作　　者：梁艳 吴雪琼 张俊仙 白雪娟 阳幼荣 李宁 余琦 李忠明 王兰 史迎昌 

机构地区：[1]解放军第三〇九医院全军结核病研究所军队结核病防治重点实验室,北京100091 [2]上海海规生物科技有限公司

出　　处：《中国防痨杂志》2012年第3期181-183,共3页Chinese Journal of Antituberculosis

基　　金："十一五"国家重大科技专项(2008ZX-10003-013);WHO基金(V25-181-202);国家自然科学基金(30070730)

摘　　要：结核病是由Mtb引起的一种呼吸道传染病,全球结核病疫情仍然十分严峻,而卡介苗预防结核病的效果并不理想,研究新型结核病疫苗已成为国内外结核病研究的热点之一。将本课题组自1998年至今研究MtbAg85ADNA疫苗的免疫原性、治疗效果进行综合与概述,结果表明Mtb Ag85ADNA疫苗可诱导小鼠体液免疫和Th1型细胞免疫应答,可减少小鼠组织中的Mtb尤其是耐多药Mtb的数目,该疫苗与常规化疗联合不仅可提高机体免疫力,并可有效地杀灭或抑制Mtb,从而提高化疗效果。Tuberculosis is a respiratory infectious disease caused by Mycobacterium tuberculosis,and the situation of tuberculosis（TB） in the world is still very severe.While the effect of currently available vaccine Bacillus Calmette-Guérin（BCG） against TB,is not ideal.A new tuberculosis vaccine has become one of the hotspots in the research of tuberculosis at home and abroad.This article will introduce the immunogenicity and therapeutic effects of Mtb Ag85A DNA vaccine in the mouse tuberculosis model from our research team since 1998.The results showed that Mtb Ag85A DNA vaccine could induce humoral immune and Th1 cell immune responses in mice,reduce M.tuberculosis,especially multi-drug-resistant M.tuberculosis in the organs of mice.The vaccine combined with conventional chemotherapy can improve the immunity,and effectively kill or inhibit M.tuberculosis,so as to improve the effect of chemotherapy.

关 键 词：疫苗 DNA 抗原85A 抗原 细菌 结核/治疗 

分 类 号：R392[医药卫生—免疫学]