高效液相色谱法-二极管阵列检测器考察注射用头孢唑啉钠与注射用氯诺昔康的配伍稳定性  

Stability and compatibility of cefazolin sodium and lornoxicam by high performance liquid chromatography-diode array detection

作　　者：时晓亚[1] 方宝霞[1] 陈富超[1] 朱军[1] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008

出　　处：《新乡医学院学报》2012年第3期182-184,共3页Journal of Xinxiang Medical University

摘　　要：目的考察注射用头孢唑啉钠与注射用氯诺昔康在氯化钠注射液中的配伍稳定性。方法在室温条件下,采用高效液相色谱法-二极管阵列检测器测定头孢唑啉钠与氯诺昔康配伍后0～6 h内的含量变化,并观察和检测此2种药配伍液的外观与pH值变化。结果在室温下,配伍液6 h内的含量、pH及外观均无明显变化。结论室温条件下,注射用头孢唑啉钠与注射用氯诺昔康在氯化钠注射液中6 h内保持稳定。Objective To study the the stability and compatibility of cefazolin sodium injection with lornoxicam in sodium chloride injection. Methods At room temperature,the changes in contents of cefazolin and lornoxicam were determined simultaneously by high performance liquid chromatography-diode array detection（HPLC-DAD）,and the changes in appearance,pH value were observed within 6 hours. Results No significant differences were found in the content,colour and pH value for the mixed solution determined at different time within 6 hours after mixing at room temperature. Conclusion The mixture of cefazolin sodium injection with lornoxicam in sodium chloride injection at ambient temperature are stable within 6 hours.

关 键 词：头孢唑啉钠 氯诺昔康 高效液相色谱法 配伍 稳定性 

分 类 号：R969.2[医药卫生—药理学]