青蒿素哌喹片联合伯氨喹治疗科摩罗无并发症恶性疟临床疗效观察(英文)  

Clinical Trial of Artequick-Primaquine for the Treatment of 155 Falciparum Malaria Patients in Comoros

作　　者：邓长生[1] 宋健平[1] 谈博[1] Mariata Rahamatou Ali Silai Abobacar Soulaiman Moussa Mohamed Ahamada MSA Mliva 李国桥[1] 

机构地区：[1]广州中医药大学青蒿研究中心,广东广州510405 [2]科摩罗国家疟疾中心和国家中心医院 [3]科摩罗米察米乌利中心医院 [4]科摩罗义隆中心医院

出　　处：《广州中医药大学学报》2012年第2期197-201,共5页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：Guangdong Provincial Science and Technology Foundation(No.2008A050200007)

摘　　要：【目的】评价青蒿素哌喹片联合伯氨喹治疗科摩罗恶性疟有效性和安全性,验证青蒿素哌喹片—伯氨喹治疗非洲恶性疟的有效临床剂量。【方法】共观察了无并发症恶性疟患者155例。成人口服青蒿素哌喹片—伯氨喹片1次/d,2片/次,连续2 d,1个疗程共4片(青蒿素320 mg,哌喹1 500 mg,伯氨喹16 mg);6岁以下儿童使用青蒿素哌喹片—伯氨喹颗粒剂。28 d后观察复燃率、平均原虫清除时间、平均退热时间、副作用等。【结果】服药后患者临床症状快速缓解。平均原虫清除时间(PCT)为(51.0±25.9)h,平均退热时间为(20.8±11.4)h。患者对青蒿素哌喹片—伯氨喹有良好的耐受性。只有少数患者出现恶心、呕吐和头晕等不良反应,副作用发生局限且能自愈。患者用药前及开始用药后的第7天观察血常规、生化检查未见明显毒副作用。【结论】青蒿素哌喹片—伯氨喹治疗无并发症恶性疟具有高效、速效、副作用低和疗程短等特点。Objective To evaluate the efficacy and safety of ArtequickPiperaquine fixed combination （ArtequickPrimaquine） for the treatment offalciparum malaria in Comoros, and to investigate the clinical dosage of ArtequickPrimaquine for the treatment offalciparum malaria in Africa. Methods One hundred and fiftyfive falciparum malaria patients without complications were enrolled into the trial. ArtequickPrimaquine tablets were administrated for adults orally once daily （2 tablets ）, 2day regimen, and the total dosage were 4 tablets （including Artemisinin 320 mg, Piperaquine 1 500 rag, Primaquine 16 rag）. ArtequickPrimaqine granules were used to for patients under 6 years old. Followup was carried out for the observation of cure rate, recrudescence rate, mean parasite recrudescence time, mean fever clearance time and side effects for 28 days. Results Clinical symptoms were alleviated quickly after drug administration. The mean parasite clearance time （PCT） and mean fever clearance time （FCT） were 51.0 25.9 hrs and 20. 8 11.4 hrs, respectively. Patients were well tolerated to ArtequickPrimaquine tablets. Only few of them had adverse reaction of nausea, vomiting and dizziness, and these adverse reactions were selflimited. No obvious toxicity was found in the comparison of indicators of hematological tests, biochemical examination before treatment and 7 days after the drug administration. Conclusion ArtequickPrimaquine has advantages of high efficacy, quick action, few side effects and short regiment for the treatment offalciparum malaria in Comoros.

关 键 词：青蒿素哌喹片-伯氨喹片/治疗应用 恶性疟 科摩罗 

分 类 号：R531.3[医药卫生—内科学]