A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats  

作　　者：Xuntai Ma Yong Tang Yang Lv Oumei Cheng Yong Yan 

机构地区：[1]Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China [2]Department of Histology and Embryology, Institute of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China [3]Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China [4]Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

出　　处：《Neural Regeneration Research》2012年第4期268-272,共5页中国神经再生研究（英文版）

基　　金：supported by Talent Foundation of the Affiliated Hospital of Luzhou Medical College, No. 09057;Youth Researcher Foundation of Luzhou Medical College, No. 09013;Key Program of the Education Department of Sichuan Province, No. 09ZA046;Scientific Research Foundation of the Health Department of Sichuan Province, No. 090231;a grant from Science and Technology Bureau of Luzhou, No. (2009)1

摘　　要：An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.

关 键 词：cortical dysplasia heterotopic nodules white matter myelinated fibers medullary sheath STEREOLOGY 

分 类 号：S831.1[农业科学—畜牧学] Q426[农业科学—畜牧兽医]