修复基因XRCC1 Arg280His多态性在肝癌发病机制中的研究  

Study of polymorphisms of DNA repair gene XRCC1 and hepatic cancer

作　　者：薄挽澜[1] 张贵贤 李冬月[1] 王玺[1] 

机构地区：[1]哈尔滨医科大学附属第一医院消化内科,黑龙江哈尔滨150001 [2]天津市传染病院,天津310000

出　　处：《哈尔滨医科大学学报》2012年第1期43-45,共3页Journal of Harbin Medical University

基　　金：黑龙江省教育厅资助项目(11541244)

摘　　要：目的探讨DNA损伤修复基因XRCC1多态与肝癌遗传易感性的关系。方法选取了90例肝癌患者及90例正常自愿对照者进行研究,采用限制性片段长度多态性方法,比较不同基因型与肝癌发病的关系。结果变异型等位基因XRCC1 Arg/His及His/His的出现率在肝癌组和对照组中分别为28.89%和13.33%,P<0.05;而野生基因型XRCC1 Arg/Arg出现率在肝癌组和对照组中分别为71.11%和86.67%,P>0.05。结论 XRCC1基因Arg280His单核苷酸多态在肝癌的发生机制中起着至关重要的作用。Objective To evaluate the association between polymorphisms of XRCC1 and riskof hepatic cancer. Methods The polymorphisms of XRCC1 in 90 histological contirmed hepat- ic cancer patients and 90 free controls were studyed, and the two polymorphisms were geno- typed by using polymerase chain reaction-restriction fragment length polymorphisms （PCR- RFLP）. Results The frequency of Arg/His and His/His for variant XRCC1 in cases and con- trols were 28.89% and 13.33%, respectively, obvious higher in patients tha~ that in controls, P 〈0.05. But the frequency of Arg/Arg in cases and controls were 71.11% and 86. 67% ,P 〉0. 05. Conclusion The XRCC1 Arg280His may contribute to the developing hepatic canc- er

关 键 词：肝癌 XRCC1 基因多态性 

分 类 号：R512.62[医药卫生—内科学]