DNA修复基因XPCC3多态性与子宫内膜异位症发病相关性分析  

Research of the relationship between polymorphisms of DNA repair gene XRCC3 and endometriosis

作　　者：邹丽红[1] 徐帅[2] 卢美松[1] 

机构地区：[1]哈尔滨医科大学附属第一医院妇科腔镜中心,黑龙江哈尔滨150001 [2]黑龙江中医药大学附属第一医院妇产科,黑龙江哈尔滨150040

出　　处：《哈尔滨医科大学学报》2012年第1期46-48,共3页Journal of Harbin Medical University

摘　　要：目的研究DNA修复基因XRCC3多态性与子宫内膜异位症发病风险的关系。方法采用病例-对照研究的方法,应用PCR-RELP方法检测子宫内膜异位症患者与非子宫内膜异位症妇女XRCC3基因Thr241Met的多态性分布,并分析其多态性与子宫内膜异位症疾病病理过程的关系。结果XRCC3基因多态性在内异症组与对照组存在显著差异(P<0.05),Thr/Met基因表达在内异症组显著增强(P<0.05);Thr241Met基因多态性与内异症病理分期无相关性。结论具有XRCC3 Thr/Met基因型或Met等位基因的个体对内异症的发生有易感性,但与内异症的临床病理分期无关。Objective To investigate the association of the polymorphisms in DNA repair gene XRCC3 with endometriosis risk. Methods The polymorphisms of DNA repair gene XRCC3 between endometriosis patients and controls were detected and whether XRCC3 were associated with the severity of endometriosis or not was evaluated. Genotypes of XRCC3 were analyzed by PCR-RELP. Results There was significantly difference between endometriosis and control groups of XRCC3 genetic polymorphism （P 〈 0.05 ）. The expression of Thr/Met gene was sig- nificantly enhanced in endometriosis （P 〈 0.05 ）. There was not association between the distri- butions of genotypes or alleles of XRCC3 and the stage of endometriosis. Conclusion Patients with XRCC3 Thr/Met or Met allele genotype have susceptibility to endometriosis, but the geno- type is not associated with the stage of endomtriosis.

关 键 词：子宫内膜异位症 XRCC3基因 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学]