楂七降脂袋泡茶剂对非酒精性脂肪肝大鼠肝脏脂质代谢和肝组织形态学的影响  

Effects of Zhaqi Reduced-fat Teabags on Liver Lipid Metabolism and Liver Tissue Morphology in Nonalcoholic Fatty Liver Disease Rats

作　　者：李俊贤[1] 曹永常[1] 余敏[1] 余红运[1] 姚军[1] 黄孟君[2] 周薪蓓[2] 

机构地区：[1]湖南中医药大学,长沙410007 [2]湖南中医药大学第一附属医院

出　　处：《浙江中西医结合杂志》2012年第3期169-171,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：湖南省研究生科研创新基金项目(No.CX2010B352)

摘　　要：目的:观察楂七降脂袋泡茶剂对NAFLD大鼠脂质代谢和肝组织形态学的影响。方法:高脂饲料制备SD大鼠非酒精性脂肪肝模型,50只大鼠造模成功后,随机分为模型组,降脂通络组,楂七降脂袋泡茶高、中、低剂量组。连续灌胃给药4周后,从腹主动脉采血测定血脂及肝功能,采血后处死,剖腹摘取肝脏进行形态学观察。结果:楂七降脂袋泡茶剂能明显降低模型大鼠血清、肝脏组织TC、TG含量,降低血清ALT、AST(P<0.05),改善肝组织脂肪变程度。结论:楂七降脂袋泡茶剂能够促进脂质代谢、保护肝功能,具有良好的抗非酒精性脂肪肝作用。Objective： To explore the effect of Zhaqi reduced-fat teabags（Zhaqi） on liver lipid metabolism and liver tissue morphology in nonalcoholic fatty liver disease （NAFLD） rats. Methods： Sprague Dawley rats with NAFLD was prepared with high fat forage. Fifty model rats were randomly divided into model group, 3 Zhaqi groups with high, middle and low dosages, and Jiangzhitongluo group, 10 in each. After 4-week continuous administration, blood samples were drawn from the abdominal aorta for examination of blood lipids and liver function. All rats were sacrificed after blood drawing for observation of hepatic tissue morphology. Results： Zhaqi of the above 3 dosages all obviously reduced the serum levels of TC, TG, and ALT and AST and attenuated the damage of liver tissue, compared with other groups （P〈0.05）. Conclusion： Zhaqi reduced-fat teabags can promote lipid metabolism and protect liver function of NAFLD rats.

关 键 词：大鼠 非酒精性脂肪肝 楂七降脂袋泡茶剂 脂质代谢 形态学 

分 类 号：R285.5[医药卫生—中药学]