Isolation of metabolic products from the fungus Nectria sp.HLS206 that is associated with the marine sponge Gelliodes carnosa collected from the South China Sea  

中国南海丰肉结海绵相关丛赤壳属真菌HLS206代谢产物研究(英文)

作　　者：王瑞杉[1] 巩婷[1] 朱平[1] 程克棣[1] 

机构地区：[1]中国医学科学院、北京协和医学院药物研究所、天然药物活性物质与功能国家重点实验室、卫生部天然药物生物合成重点实验室,北京100050

出　　处：《Journal of Chinese Pharmaceutical Sciences》2012年第2期183-186,共4页中国药学（英文版）

基　　金：National Science and Technology Project of China(Grant No.2009ZX09301-003-4-1)

摘　　要：The sponge-associated fungus Nectria sp.HLS206,which belongs to the order of Hypocreales,was isolated from the marine sponge Gelliodes carnosa collected from the South China Sea.The secondary metabolites of the fungus were isolated.From the solid cultures,five compounds were purified,which are chalmicrin（1）,hypocrealesate（2）,fucosterol（3）,stigmasterol（4） and β-sitosterol（5）.The structures of the 5 compounds were elucidated by ESI-MS,1D and 2D NMR spectra（COSY,HMQC and HMBC）.To the best of our knowledge,it is the first time compound 1 was isolated from the order of Hypocreales,and the spectral data of compound 2 are also firstly reported.海绵相关真菌丛赤壳属HLS206系肉座菌目真菌,分离自我国南海丰肉结海绵。本文对HLS206进行了次生代谢产物研究,通过发酵培养分离得到5个化合物,并应用质谱及一维和二维核磁共振(COSY,HMQC和HMBC)等方法进行结构鉴定,分别确定为chalmicrin(1)、hypocrealesate(2)、岩藻甾醇(3)、豆甾醇(4)和β-谷甾醇(5)。化合物1为首次从肉座菌目真菌中分离获得;化合物2的有关波谱数据为首次报道。

关 键 词：Sponge-associated fungus Nectria sp. Secondary metabolites Spectral data 

分 类 号：R284.2[医药卫生—中药学]