Immunosuppressive exosomes from TGF-pl gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells  

作　　者：Zhijian Cai Wei Zhang Fei Yang Lei Yu Zhou Yu JihHung Pan Lie Wang Xuetao Cao Jianli Wang 

机构地区：[1]Institute of lmmunology,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China [2]Hangzhou Wahaha group Co.Ltd.,Hangzhou,Zhejiang 310018,China

出　　处：《Cell Research》2012年第3期607-610,共4页细胞研究（英文版）

基　　金：Acknowledgments We thank Ms Diya Yang for technical assistance. This work was supported by the National Key Basic Research Program of China （2007CB512403）, the National Natural Science Foundation of China （30972725 and 31070795）, the National Technology Key Projects of China （008ZX1002-008） and the Natural Science Foundation of Zhejiang Province （Z2090042）.

摘　　要：Dear Editor, Inflammatory bowel disease （IBD）, including ulcerative colitis and Crohn＇s disease, is generally believed to originate from the complicated interactions between genetic factors and commensal flora. This leads to the breakdown of innate immunity and the aberrant activation of the immune system,

关 键 词：调节性T细胞 自身免疫性疾病 树突状细胞 免疫抑制 基因修饰 炎症 溃疡性结肠炎 介导 

分 类 号：S858.31[农业科学—临床兽医学] Q2[农业科学—兽医学]