有机阴离子转运多肽1B1 521T〉C基因多态性与原发性高血压的相关性  

The correlation between the OATP1B1 521T 〉 C genetic polymorphism and essential hypertension

作　　者：叶丽丽 邱健 赵树进 洪长江 肖飞 邹育海 

机构地区：[1]广州军区广州总医院心血管内科,广东省广州市,510010 [2]广州军区广州总医院药学部,广东省广州市,510010

出　　处：《中国基层医药》2012年第5期646-648,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：广东省科技计划项目（20098080701105）

摘　　要：目的探讨有机阴离子转运多肽181（OATP1B1）521T〉C与原发性高血压的相关性。方法采用实时荧光定量TaqMan—MGB探针法，检测164例原发性高血压患者和159例非高血压对照者OATP1B1521T〉C的基因型，并将其检测结果与DNA测序结果进行比较。结果高血压组OATP1BI521T〉c的T／C基因型频率明显低于对照组（16％、25％，P〈0．05），且OATP1B1521T〉C的c等位基因频率明显低于对照组（10％、17％，P〈0．05），而Logistic回归分析法对影响高血压的相关因素进行回归分析，亦显示OATP1B1521T〉C基因多态性与高血压有相关性（P〈0．05）。结论SLC01BI的521T〉C突变为中国原发性高血压人群中的常见突变，在原发性高血压人群和血压正常人群之间的分布有差异；SLC0181的52IT〉C突变与原发性高血压的发病之间可能具有相关性。Objective To study the relationship between the OATP1B1 521T 〉 C genetic polymorphism and essential hypertension. Methods 164 essential hypertension subjects and 159 normotensive subjects were detected by the TaqMan-MGB probe real-time fluorescence quantitative PCR, and the results were compared with those of DNA sequencing. Results The frequencies of T/C genotype and C allele of OATP1B1 521T 〉 C gene of the essential hypertension subjects were obviously lower than those of the normotensive subjects（T/C genotype ：0.16 vs 0.25 ,P 〈 0.05 ; C allele ：0.10 vs 0.17 ,P 〈 0.05 ） ,The difference was significant. Binary logistic stepwise regression analysis was used for evaluatine the risk factors of essential hypertension, there was significant relationship between OATP1 B1 52IT 〉 C gene polymorphism and essential hypertension. Conclusion The SLCO1 B1 521T 〉 C variant was common in Chinese essential hypertension population,but the difference of frequency of SLCO1B1 521T 〉 C muton between the essential hypertension patients and the normotensive controls was of obviously statistical significance, which indicates that the SLCO1B1521T 〉 C variant maybe associate with essential hypertension,

关 键 词：OATP1B1 521T〉c 基因 多态性 原发性高血压 

分 类 号：R544.1[医药卫生—心血管疾病]