氯吡格雷对不稳定型心绞痛患者血浆内皮素和降钙素基因相关肽的影响  

Effect of Clopidogrel on Plasma Endothelin and Calcitonin Gene Related Peptide in Patients with Unstable Angina Pectoris

作　　者：朱铭[1] 芦涤[1] 张敏莉[1] 魏洪杰[1] 金鹏[1] 

机构地区：[1]中国石油天然气集团公司中心医院心内科,河北省廊坊,065000

出　　处：《中国基层医药》2012年第5期699-700,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨氯吡格雷对不稳定型心绞痛（UAP）患者血浆内皮素和降钙素基因相关肽的影响。方法将100例UAP患者随机分为两组，分别用消心痛（50例）及氯吡格雷加消心痛（50例）联合治疗，采用放免法观察治疗前后患者血浆内皮素（ET）及降钙素基因相关肽（CGRP）含量，另选20名健康体检者作对照。结果与健康志愿者相比，UAP患者血浆ET含量明显升高（P〈0．05），CGRP明显降低（P〈0．05）。较消心痛治疗组相比，联合使用氯吡格雷治疗后患者ET明显下降（P〈0．01），CGRP明显升高（P〈0．05）。结论氯吡格雷能显著改善ET、CGRP代谢失衡状况，是治疗UAP的有效药物。Objective To investigate the effect of Clopidogrel on the plasma endothelin（ET） and calcitonin gene related peptide （CGRP） in patients with unstable angina pectoris （UAP）. Methods Patients with UAP were divided into two groups, the regular treated group （ n = 50） was treated with Isoket and the Danshen group （ n = 50） was treated with combined Isoket and Clopidogrel. The plasma ET and CGRP were measured before and after treatment by radioimmunoreactive assay. Data were compared between the two groups and also compared with those measured in 20 healthy subjects for control. Results ET level was significantly higher and CGRP level was lower in UAP patients than that in healthy subjects（P 〈0.05 ）. After Clopidogrel treatment,ET was significantly decreased（ P 〈 0.01 ） and CGRP increased（P 〈 0.05） in combined treatment group compared with patients received lsoket only. Conclusion Clopidogrel was an effective drug for UAP treatment,which could efficiently regulate the ET and CGRP metabolism.

关 键 词：氯吡格雷 不稳定型心绞痛 内皮素 降钙基因相关肽 

分 类 号：R541.4[医药卫生—心血管疾病]