重组人粒细胞巨噬细胞集落刺激因子喷雾剂对放化疗口腔黏膜炎干预作用的临床研究  

作　　者：陈楚云[1] 林连兴[1] 杨小虹[1] 

机构地区：[1]中山大学附属汕头医院放射治疗科,广东汕头515031

出　　处：《国际护理学杂志》2012年第3期404-406,共3页international journal of nursing

基　　金：本研究为汕头市科技局立项项目（20114640）

摘　　要：目的探讨放化疗所致口腔黏膜反应的有效防治措施。方法将我院2010年1月-2011年7月100例头颈部恶性肿瘤放化疗患者随机分为2组，试验组采用重组人粒细胞巨噬细胞集落刺激因子（rhGM—CSF）喷雾剂治疗放化疗所致口腔黏膜炎；对照组以安慰剂对照，辅以健康教育和整体护理，观察两组药物的疗效、疼痛缓解度和安全性。结果实验组的有效率为86％，对照组的有效率为32％，两组问差异有统计学意义（P〈0．05）。试验组患者口腔疼痛缓解总有效率为76．0％，对照组为57．1％。实验组疼痛缓解显著优于对照组（P〈0．05）。结论使用（rhGM—CSF）喷雾剂能明显减轻放化疗所致121腔黏膜炎，且安全性好，使用方便。Objective To explore an effective preventive measures for the oral mucosa reaction caused by chemo - radiotherapy.Methods A total of 100 cases of patients with head and neck malignant tumor undergone radiation and chemotherapy were randomly divided into two groups.The test group was treated with human recombinant granulocyte macrophage colony stimulating factor ( rhGM - CSF),and the control group was treated with placebo,accompanied by health education and holistic nursing care.Effectivity,pain relief and safety of rhGM - CSF in treatment of oral mucosal inflammation were evaluated between two groups.Results Total effective rate was noted in 86％ patients in test group and 32％ patients in control group respectively.The difference between the two groups was significant ( P ＜0.05).Pain relief was noted in 76.0％ patients in test group and 57.1％ patients in control group respectively.The difference between two groups was significant ( P =0.047 ).Conclusions rhGM - CSF was an effective preventive measure for treatment of oral mucosal inflammation caused by radiation and chemotherapy with good safety and convenient use.

关 键 词：rhGM—CSF喷雾剂 放化疗口腔黏膜 治疗和护理 

分 类 号：R473.73[医药卫生—护理学]