5-氟尿嘧啶/纳米蒙脱土缓释药物的制备及性能  

Sustained-release 5-fluorouracil/nano montmorillonite: preparation and property evaluation

作　　者：田智慧[1] 路新卫[2,3] 朱全红[3] 朱志博[2] 韦莉萍[3] 丁婷[3] 周春琼[2] 

机构地区：[1]南方医科大学南方医院,广东省广州市510515 [2]南方医科大学药学院,广东省广州市510515 [3]南方医科大学中医药学院,广东省广州市510515

出　　处：《世界华人消化杂志》2012年第5期414-417,共4页World Chinese Journal of Digestology

基　　金：广东省自然科学基金资助项目;No.7300452~~

摘　　要：目的:制备5-氟尿嘧啶/纳米蒙脱土缓释系统,并对其进行体外释药研究.方法:采用离子交换法将5-氟尿嘧啶插层到蒙脱土片层间,通过X射线衍射(X ray diffraction,XRD)和FTIR对5-氟尿嘧啶/纳米蒙脱土缓释系统的性能进行表征,紫外分光光度计定量分析药物的体外累积释药量.结果:插层后的蒙脱土层间距由1.492 nm增大到1.736 nm,说明5-氟尿嘧啶已经成功插入蒙脱土片层间;药物体外持续释放时间超过6 h,证实制备的复合药物具有良好的缓释效果.结论:5-氟尿嘧啶/纳米蒙脱土缓释系统具有良好的缓释效果.AIM： To prepare sustained-release 5-fluoroura- cil/nano montmorillonite and and to evaluate its in vitro release characteristics. METHODS： 5-fluorouracil was intercalated into the interlayer of montmorillonite by ion- exchange, The in vitro release characteristics of 5-fluorouracil/nano rnontmorillonite were ana- lyzed by XRD and FTIR. RESULTS： The spacing of 5-fluorouracil/nanomontmorillonite increased from 1.492 nm to 1.736 nm, showing that 5-Fu had been intercalated into the interlayer of Ca-MMT. Sustained release of 5-fluorouracil in vitro exceeded 6 h, proving that the composite has a good slow-release property. CONCLUSION： 5-fluorouracil/nano montmorillonite possesses a wonderful sustained-release property.

关 键 词：5-氟尿嘧啶 纳米蒙脱土 缓释 

分 类 号：R943[医药卫生—药剂学]