噁喹酸在大菱鲆体内的药代动力学研究  

Pharmacokinetics of Oxolinic Acid in Turbot(Scophthalmus maximus) After a Single Oral and Intravenous Administration

作　　者：孙爱荣[1,2] 李健[2] 常志强[2] 梁俊平[2] 

机构地区：[1]上海海洋大学水产与生命学院,上海201306 [2]中国水产科学研究院黄海水产研究所,农业部海洋渔业资源可持续利用重点开放实验室,山东青岛266071

出　　处：《中国海洋大学学报（自然科学版）》2012年第3期75-79,共5页Periodical of Ocean University of China

基　　金：国家自然科学基金项目(30700617);公益性农业行业专项(nyhyzx07-046)资助

摘　　要：采用高效液相色谱法,研究了(24.5±0.2)℃水温条件下单次静注和口服给药后噁喹酸在健康大菱鲆体内的代谢动力学规律。结果显示,大菱鲆单次口服噁喹酸(20mg/kg)后,药物在血浆中经时过程符合一级吸收二室开放模型,表达方程为C口服=2.059e-0.062t+0.645e-0.023t-2.704e-0.202t,单次静注噁喹酸(10mg/kg)后,药物在血浆经时过程符合无级吸收二室开放模型,表达方程为C静注=12.284e-0.144t+0.284e-0.027t。血浆中的主要药动学参数,静注的t1/2α(4.813h)、t1/2β(25.441h)、tmax(0.083h)均小于口服给药(11.26、30.212、6h)。结果表明,静注噁喹酸在大菱鲆体内的吸收、消除速度,达峰时间均快于口服给药。根据本实验的结果,噁喹酸的合理给药方案为:建议口服给药按鱼体重21.41mg/kg,每日1次给药,连用5～7d。The pharmacokinetics of Oxolinic acid was studied in Scophthalmus mazimus by using the high performance liquid chromatography （HPLC）. The study was performed at （24. 5±0.2） ℃. All the health fish received a single oral administration of OA at a level of 20mg/kg and intravenous administration of OA at a level of 10 mg/kg. The results showed that the hemolymph concentration time course of OA can be described by a two-compartment open model with the first order absorption after a single oral administration. The pharmacokinetic equation was： Cpo=2. 059e^-0.062t＋0. 645e-0.023t-2. 704e^-0.202t. The hemolymph concentration-time course of OA can be described by a two-compartment open model with the zero order absorption after a single intravenous administration. The pharmacokinetic equation was： Civ= 12. 284e^-0.144t＋0. 284e^-0.027t. The peak time, distribution and elimination hail-lives （tmax, t1/2α and t1/2β） by intravenous administration were found to be 0. 083, 4. 813 and 25. 441 h which were shorter than 6, 11.26 and 30. 212 h of oral administration. The results indicated that the peak time, absorption and elimi- nate speed of intravenous administration were faster than oral administration. The scheme of oxolinic acid was established to fish bacterial diseases, with the dose of 21.41mg/kg at the interval of ld, continuous 5 -7 days by oral administration.

关 键 词：大菱鲆 噁喹酸 药代动力学 给药方案 

分 类 号：K969.1[历史地理—人文地理学]