乌鲁木齐市母婴麻疹抗体水平相关性研究  

Research of correlation of measles antibody level between infant and mother in Urumqi

作　　者：刘健[1] 巴特尔[1] 张勇 王君[1] 杨艳梅[1] 严丽 吴亚英[1] 曹琦[1] 谢彦玲 李惠敏 

机构地区：[1]新疆乌鲁木齐市疾病预防控制中心,乌鲁木齐830026 [2]乌鲁木齐市妇幼保健医院,乌鲁木齐830002

出　　处：《疾病预防控制通报》2012年第1期29-31,共3页Bulletin of Disease Control & Prevention(China)

基　　金：乌鲁木齐市卫生局科技计划项目(201007)

摘　　要：目的了解母传麻疹抗体的基础水平对新生儿获得被动抗体的影响,为科学地制定预防麻疹措施、降低小月龄儿童麻疹发病提供依据。方法对乌鲁木齐市妇幼保健医院住院生产的产妇进行问卷调查,采集静脉血及新生儿脐血,用酶联免疫吸附法(ELISA)定量检测麻疹IgG抗体。结果调查的105对母婴中,母亲麻疹抗体阳性率80%,新生儿麻疹抗体阳性率84.76%,母亲抗体几何平均浓度(GMC)为799.71 mIU/ml,新生儿GMC为1 048.41 mIU/ml。母亲抗体滴度与新生儿抗体滴度有显著的正相关(r=0.873)。结论产妇血清麻疹抗体水平较低,使得所生的婴儿一出生麻疹抗体水平就达不到保护性水平,成为易感人群。对申请结婚及计划怀孕前的妇女加强麻疹疫苗免疫接种,可大大降低8月龄以内婴儿的麻疹发病率。Objective To understand effect of basal level of maternal-transferred measles antibody on acquirement of passive immunization for new born,to provide basis for scientific prevention measure of measles and decreasing incidence rate of low-age infants.Methods Questionnaires were conducted in parturient in Urumqi Municipal Hospital of Maternal and Child Health.Venous blood of the parturient and umbilical cord blood of their neonates were collected to detect for serum antibody to measles by ELISA.Results Out of the 105 pairs investigated,the positive rate of serum antibody of mother and new born was 80% and 84.76%,respectively,with GMC of the new born of 1 048.41 mIU/ml and mother of 799.71 mIU/ml.The correlation coefficient of antibody titer between mother and infant was 0.873,showed significantly positive correlation.Conclusions The measles antibody level of parturient is low.It makes measles antibody of infants to be born under protection level,and they become susceptible population.Therefore,it is a feasible strategy to strengthen measles vaccine inoculation in the population,in order to effectively decrease measles incidence rate in 8-month-old infants.

关 键 词：母婴 抗体水平 麻疹 相关性 

分 类 号：R511.1[医药卫生—内科学] R181.81[医药卫生—临床医学]