环胞素A联合纳洛酮治疗重型颅脑损伤的临床研究  

Clinical Observation in Therapeutic Effects of Cyclosporine A Combined with Naloxone in the Treatment of Severe Brain Injury

作　　者：汪更胜[1] 朱新林[1] 

机构地区：[1]中国人民解放军第163医院急诊科,长沙410022

出　　处：《中国现代手术学杂志》2012年第1期61-62,共2页Chinese Journal of Modern Operative Surgery

摘　　要：目的探讨环胞素A联合纳洛酮治疗重型颅脑损伤的疗效以及安全性。方法选取我院52例急性重型颅脑损伤患者为研究对象,随机分为A、B两组,其中A组重型颅脑损伤患者给予一般常规治疗,B组在常规治疗的基础上加用环胞素A和纳洛酮。结果 B组治疗效果明显优于A组,主要表现在患者觉醒时间早,呼吸循环功能恢复稳定较快,呼吸异常和心电图异常明显减少,颅内压显著降低(P<0.05)。结论环胞素A联合纳洛酮治疗重型颅脑损伤,患者具有较好的反应性和耐受性。Objective To evaluate the efficacy and safety of cyclosporine A plus naloxone in the treatment of severe brain injury.Method 52 patients diagnosed as severe brain injury were randomly assigned to receive the regimen of general conventional treatment（n=26,group A） or cyclosporine A plus naloxone（n=26,group B）.Results The clinical results of Group B were significantly better than Group A,mainly in the early awakening time,stable and rapid recovery of the respiratory and circulatory function,normal electrocardiogram and lower the intracranial pressure（P0.05）.Conclusion The regimen of cyclosporine A plus naloxone is effective for severe brain injury with tolerable adverse effects.

关 键 词：环胞菌素 纳洛酮 颅脑损伤 

分 类 号：R651.15[医药卫生—外科学]