Determinants of public T cell responses  

作　　者：Hanjie Li Congting Ye Guoli Ji Jiahuai Han 

机构地区：[1]State Key Laboratory of Cellular Stress Biology and School of Life Sciences,Xiamen University,Xiamen,Fujian 361005,China [2]Department of Automation,Xiamen University,Xiamen,Fujian 361005,China

出　　处：《Cell Research》2012年第1期33-42,共10页细胞研究（英文版）

基　　金：This work was supported by the National Basic Research Pro- gram of China （973 Program; 2009CB522200）, the National Natu- ral Science Foundation of China （30830092, 30921005, 91029304, 81061160512, 61174161）, Sino-Swiss International Collaboration Grant （2009DFA32760）, the Science Planning Program of Fujian Province （2009J1010）, the Specialized Research Fund for the Doc- toral Program of Higher Education of China （20090121110022）, and the Fundamental Research Funds for the Central Univer- sities of Xiamen University （2011121047, 201112G018 and CXB2011035）.

摘　　要：Historically, sharing T cell receptors （TCRs） between individuals has been speculated to be impossible, consider- ing the dramatic discrepancy between the potential enormity of the TCR repertoire and the limited number of T cells generated in each individual. However, public T cell response, in which multiple individuals share identical TCRs in responding to a same antigenic epitope, has been extensively observed in a variety of immune responses across many species. Public T cell responses enable individuals within a population to generate similar antigen-specific TCRs against certain ubiquitous pathogens, leading to favorable biological outcomes. However, the relatively concentrated feature of TCR repertoire may limit T cell response in a population to some other pathogens. It could be a great ben- efit for human health if public T cell responses can be manipulated. Therefore, the mechanistic insight of public TCR generation is important to know. Recently, high-throughput DNA sequencing has revolutionized the study of immune receptor repertoires, which allows a much better understanding of the factors that determine the overlap of TCR repertoire among individuals. Here, we summarize the current knowledge on public T-cell response and discuss fu- ture challenges in this field.

关 键 词：public T cell response convergent recombination recombinatorial biases thymic selection 

分 类 号：S852.4[农业科学—基础兽医学] TM54[农业科学—兽医学]