海藻酸钠对氯霉素在滴眼液中缓释作用研究  

Influence of Sodium Alginate on Chloramphenicol Release in Eye Drops

作　　者：李鹏[1,2] 贾瑞[1,2] 贺艳丽[1,2] 

机构地区：[1]山东大学药学院,山东济南250012 [2]山东省生物药物研究院,山东济南250101

出　　处：《食品与药品》2012年第2期102-104,共3页Food and Drug

摘　　要：目的研究海藻酸钠对氯霉素在滴眼液中释放的影响。方法配制影响因素不同的氯霉素溶液,采用side-bi-side扩散池,测定药物渗透速率。结果氯霉素释放速率随溶液黏度增加而降低,随氯霉素浓度增加而提高。结论氯霉素在滴眼液中的释放速率与溶液黏度和药物浓度有关,适当增加海藻酸钠含量可延缓其释放速率。Objective To study the influence of sodium alginate on chloramphenicol release in eye drops. Methods The penetration rates of chloramphenicol were determined with side-N-side diffusion cell in solutions with different influence factors. Results The release rate of chloramphenicol was decreased with the viscosity increase of solutions, and increased with the increase of chloramphenicol＇ s concentration. Conclusion The release rate of chloramphenicol in eye drops is in association with the viscosity of solutions as well as its concentration, which can be decreased by increasing the concentration of sodium alginate to some extent.

关 键 词：海藻酸钠 氯霉素 药物释放 

分 类 号：R988.1[医药卫生—药品]