生物活性测定法评价银黄注射液解热质量的实验研究  

Establishment of Bioactivity Assay for Yinhuang Injection by Antipyretic Effect

作　　者：祝清芬 国明 郝玲玲 

机构地区：[1]山东省药品检验所,山东济南250101

出　　处：《食品与药品》2012年第2期125-127,共3页Food and Drug

摘　　要：目的建立银黄注射液生物活性测定法的质量标准。方法用内毒素造成家兔发热模型,观察银黄注射液的解热作用,以采用生物活性测定法评价药品质量。结果静脉注射细菌内毒素可引起家兔稳定的发热,银黄注射液对细菌内毒素所致家兔体温升高有明显抑制作用。结论可以采用药物对细菌内毒素所致家兔发热模型的影响评价银黄注射液的生物活性。Objective To establish the criteria of bioactivity assay for Yinhuang Injection. Methods The endotoxininduced febrile New Zealand rabbits were chosen as experimental models. The antipyretic effect of Yinhuang Injection was observed and the bioactivity assay was used to estimate the quality of this drug. Results The fever model of rabbits was well established by intravenous injection of endotoxin. Yinhuang Injection had obvious antipyretic effect on the endotoxin-induced febrile rabbits. Conclusion The antipyretic effect of Yinhuang Injection on endotoxininduced febrile rabbits can be used to estimate the quality of this drug as a bioactivity assay.

关 键 词：银黄注射液 解热 药效学 生物检定 

分 类 号：R282.71[医药卫生—中药学]