CXCR4和MMP-9在胃癌组织中表达及其意义  

Expression of CXCR4 and MMP-9 in Gastric Cancer and Its Significance

作　　者：徐斌 韩绍伟[2] 周笑珍 蒋平[2] 李利义[2] 

机构地区：[1]温州市瓯海区人民医院,325027 [2]温州医学院附属第二医院外科,325027

出　　处：《医学研究杂志》2012年第2期104-108,共5页Journal of Medical Research

基　　金：温州市科技计划基金资助项目(Y20090061);温州市瓯海区科技计划项目(20090137)

摘　　要：目的探讨趋化因子受体4(CXCR4)和基质金属蛋白酶-9(MMP-9)在胃癌中的表达和临床意义。方法应用S-P免疫组织化学方法检测CXCR4和MMP-9在76例胃癌组织及癌旁正常胃组织中的表达水平,并分析其与胃癌临床病理因素之间的相关性。结果 CXCR4在癌旁正常胃组织中无阳性表达,在胃癌组织中的阳性表达率为55.26%;CXCR4在伴有淋巴结转移与无淋巴结转移的胃癌组织中阳性表达率分别为73.91%和36.37%,差异有统计学意义(P=0.000);CXCR4在伴有腹膜转移的胃癌组织中阳性表达表达率为100%,显著高于无腹膜转移组(39.28%,P=0.000),且同肿瘤的分化程度及浸润深度关系密切(P分别为0.000、0.001)。MMP-9在胃癌组织中阳性表达率(67.11%)明显高于癌旁正常胃组织(15.79%)(P<0.000);MMP-9的在胃癌中的阳性表达与肿瘤组织分化程度、浸润深度、伴淋巴结转移及腹膜转移有关(P分别为0.002、0.013、0.002、0.000)。CXCR4与MMP-9的阳性表达呈正相关(r=0.406,P=0.000)。结论 CXCR4和MMP-9表达强度与胃癌的恶性程度密切相关。Objective To investigate the relationship between the expression of CXCR4 and MMP-9 in gastric cancer and several clinicopathological factors.Methods A total of 76 cases of gastric cancer were enrolled in this study.Immunohistochemical staining was performed to detect the expression of CXCR4 and MMP-9 in gastric cancer.And statistical analysis technique was used to investigate the relationship between CXCR4 and MMP-9 expressions and the clinicopathological factors.Results The total positive rate of CXCR4 expression in these samples was 55.26%,but there was no positive expression in the normal stomach tissue.The positive expression of CXCR4 was higher in these cases with lymphnode metastasis than that of patients without lymphnode metastasis（73.91% vs 36.37%,P=0.000）.The positive rate of CXCR4 expression in these cases with peritoneal metastasis was higher than that of patients without peritoneal metastasis（100% vs 39.28%,P0.000）.Meanwhile,the positive rate of MMP-9 expression in normal stomach tissue and gastric cancer tissues were 15.79% and 67.11%,respectively.The positive expression of MMP-9 was higher in these cases with lymph node metastasis than that of patients without lymph node metastasis（80.43% vs 46.67%,P=0.002）.Furthermore,the positive expression of MMP-9 with peritoneal transfer group was higher than that of patients without peritoneal transfer group（100% vs 55.36%,P=0.000）.The expression level of CXCR4 and MMP-9 were closely correlated with histological cellular differentiation,invasion depth（P=0.000,0.001,0.002,0.013）,and the positive expression of CXCR4 was consistent with the positive expression of MMP-9（r=0.406,P=0.000）.Conclusion Expressions of CXCR4 and MMP-9 are closely related to the degree of malignancy of gastric cancer,which may provide an evidence for diagnosis and assessment of prognosis in gastric cancer.

关 键 词：胃癌 趋化因子受体4 基质金属蛋白酶9 临床病理因素 

分 类 号：R512.91[医药卫生—内科学]