黄体期长方案中人绒毛膜促性腺激素注射日血清孕酮水平与临床妊娠关系的研究  

Relationship between Serum Progesterone Concetrations and Pregnancy on the day of Human Chorionic Gonadotropin Adiministration during Luteal Phase Long Protocol

作　　者：张胜坤[1] 程静[1] 黄朝霞[1] 吕杰强[1] 

机构地区：[1]温州医学院附属第二医院不孕不育生殖健康中心,325027

出　　处：《医学研究杂志》2012年第2期122-125,共4页Journal of Medical Research

摘　　要：目的探讨黄体期长方案中人绒毛膜促性腺激素(HCG)注射日血清孕酮水平与临床妊娠的关系。方法回顾性分析2009年1月～2010年10月在温州医学院附属第二医院生殖中心行黄体期长方案且有完整资料的370个IVF周期。以1.0、1.5、2.0、2.5、3.0ng/ml分别作为截断值,比较不同截断值时高低孕酮组的一般临床资料、实验室指标及临床妊娠率。结果不同截断值时,两组的临床妊娠率无明显差别(P>0.05);当以1.0、1.5、2.0和2.5ng/ml为截断值时,高孕酮组获卵数、成熟卵数、HCG日雌二醇水平高于低孕酮组,差异有统计学意义(P≤0.05)。结论 IVF-ET黄体期长方案中HCG注射日孕酮水平在一定范围内升高对临床妊娠无影响,高孕酮水平可能是较多的卵泡同步发育造成的。Objective To explore the relationship between serum progesterone concentration and pregnancy on the day of human chorionic gonadotropin（HCG） during long protocol.Methods From January 2009 to October 2010,370 circles with serum progesterone measurement on the day of HCG administration for final ooeyte maturation in IVF were analyzed retrospectively in Center of Reproductive Health in The Second Affiliated Hospital of Wenzhou Medical Colleage.When the cutoff of serum progesterone were set at 1.0,1.5,2.0,2.5,3.0ng/ml,respectively,general clinical data,laboratory results and the clinical pregnancy rate between all patients at lower and higher group at different cutoff were analyzed.Results No significant difference was found with respect to pregnant rate between lower and higher serum progesterone groups at any cutoff.However,the number of oocyte retrieved was larger in higher group than in the lower group when the cutoff was 1.0,1.5,2.0 and 2.5ng/ml,and so the estriol level and mature eggs.Conclusion The serum progesterone concentration on the day of HCG administration do not influence clinical pregnant rate in the long protocol.The higher progesterone may be from the growth of more follicle synchronously.

关 键 词：黄体期长方案 HCG注射日 孕酮 临床妊娠 

分 类 号：R714.22[医药卫生—妇产科学]